Oral administration of essential oil from Psidium glaziovianum Kiaersk leaves alleviates pain and inflammation in mice.

Autor: Costa WK; Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil. wendeocosta@gmail.com., do Nascimento MF; Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil., Dos Santos CRB; Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil., Dede Oliveira FariasAguiar JCR; Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil., do Amaral Ferraz Navarro DM; Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil., Napoleão TH; Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil., Dos Santos Correia MT; Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil., Brayner FA; Instituto Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, 50670-420, Brazil.; Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil., de Oliveira AM; Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil., da Silva MV; Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Jazyk: angličtina
Zdroj: Inflammopharmacology [Inflammopharmacology] 2022 Apr; Vol. 30 (2), pp. 599-607. Date of Electronic Publication: 2022 Mar 08.
DOI: 10.1007/s10787-022-00940-0
Abstrakt: Plants of the genus Psidium have been employed in "in natura" consumption and agroindustry, and owing to the diversity of phytochemicals, the development of new pharmaceutical forms has received remarkable research interest. In this study, the essential oil obtained from Psidium glaziovianum (PgEO) leaves were evaluated antinociceptive and anti-inflammatory activities were evaluated in mouse models. Initially, PgEO was characterized by gas chromatography-mass spectrometry and gas chromatography with flame ionization detection, and the profile was dominated by sesquiterpene compounds. In the evaluation of acute antinociceptive activity (abdominal contortions induced by acetic acid, formalin, tail immersion, and hot plate tests), PgEO promoted a reduction in nociception in the chemical and thermal models. Additionally, the potential underlying mechanism was investigated using pain pathway blockers, and the results revealed a combined action of opioidergic and muscarinic pathways. The anti-inflammatory potential was confirmed by anti-edematogenic action, reduced cell migration, pro-inflammatory cytokine production, and granuloma formation in chronic processes. This study provides evidence that PgEO can be effective for the treatment of pain and acute and chronic inflammation.
(© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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