Changes of the retinal and choroidal vasculature in cerebral small vessel disease.

Autor: Geerling CF; Department of Ophthalmology, University Hospital Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Germany., Terheyden JH; Department of Ophthalmology, University Hospital Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Germany., Langner SM; Department of Ophthalmology, University Hospital Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Germany., Kindler C; Department of Neurology, University Hospital Bonn, 53127, Bonn, Germany.; German Centre for Neurodegenerative Diseases (DZNE), 53127, Bonn, Germany., Keil VC; Department of Radiology, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands., Turski CA; Department of Ophthalmology, University Hospital Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Germany., Turski GN; Department of Ophthalmology, University Hospital Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Germany., Wintergerst MWM; Department of Ophthalmology, University Hospital Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Germany., Petzold GC; Department of Neurology, University Hospital Bonn, 53127, Bonn, Germany.; German Centre for Neurodegenerative Diseases (DZNE), 53127, Bonn, Germany.; Division of Vascular Neurology, University Hospital Bonn, 53127, Bonn, Germany., Finger RP; Department of Ophthalmology, University Hospital Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Germany. robert.finger@ukbonn.de.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Mar 07; Vol. 12 (1), pp. 3660. Date of Electronic Publication: 2022 Mar 07.
DOI: 10.1038/s41598-022-07638-x
Abstrakt: Cerebral small vessel disease (CSVD) is associated with changes in the retinal vasculature which can be assessed non-invasively with much higher resolution than the cerebral vasculature. To detect changes at a microvascular level, we used optical coherence tomography angiography which resolves retinal and choroidal vasculature. Participants with CSVD and controls were included. White matter lesions were determined on magnetic resonance imaging (MRI). The retinal and choroidal vasculature were quantified using swept-source optical coherence tomography angiography. Data were analysed using linear regression. We included 30 participants (18 females; patients, n = 20; controls, n = 10) with a mean age of 61 ± 10 years. Patients had a higher mean white matter lesion index and number of lesions than controls (p ≤ 0.002). The intraindividual deviation of choriocapillaris reflectivity differed significantly between age-matched patients (0.234 ± 0.012) and controls (0.247 ± 0.011; p = 0.029). Skeleton density of the deep retinal capillaries was significantly associated with the number of lesions on MRI (β = - 5.3 × 10 8 , 95%-confidence interval [- 10.3 × 10 8 ; - 0.2 × 10 8 ]) when controlling for age. The choroidal microvasculature and the deep retinal vascular plexus, as quantified by optical coherence tomography angiography, are significantly altered in CSVD. The value of these findings in diagnosing or monitoring CSVD need to be assessed in future studies.
(© 2022. The Author(s).)
Databáze: MEDLINE
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