The clinical impact of the Covid-19 pandemic first wave on patients with cystic fibrosis in New York.

Autor: Simonson JL; Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: jsimonson2@northwell.edu., Esposito C; Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: cesposito5@northwell.edu., Frantzen T; Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: tfrantzen1@northwell.edu., Henthorne K; Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: khenthorne@northwell.edu., Espinal A; Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: aespinal2@northwell.edu., Romano S; Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: sromano1@northwell.edu., Ramdeo R; Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: rramdeo@northwell.edu., Trentacoste J; Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: jkosiorek@northwell.edu., Tsang D; Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: dtsang@northwell.edu., LaVecchia G; Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: glavecch@northwell.edu., Abdullah R; Department of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, United States. Electronic address: robert.abdullah@stonybrookmedicine.edu., Berdella M; Division of Pediatric Pulmonology, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel, New York, NY 10003, United States. Electronic address: maria.berdella@mountsinai.org., Bonitz L; Division of Pediatric Pulmonology, The Steven and Alexandra Cohen Children's Medical Center, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Lake Success, NY 11042, United States. Electronic address: lbonitz@northwell.edu., Condos R; Division of Pulmonary, Critical Care, and Sleep Medicine, NYU Langone Health, New York University Grossman School of Medicine, New York, NY 10016, United States. Electronic address: rany.condos@nyulangone.org., Constantinescu A; Division of Pediatric Pulmonology, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, New York, NY 10032, United States. Electronic address: ac726@cumc.columbia.edu., DeCelie-Germana JK; Division of Pediatric Pulmonology, The Steven and Alexandra Cohen Children's Medical Center, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Lake Success, NY 11042, United States. Electronic address: jgermana@northwell.edu., DiMango E; Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, New York, NY 10032, United States. Electronic address: ead3@cumc.columbia.edu., Draine M; Division of Pulmonary, Critical Care, and Sleep Medicine, NYU Langone Health, New York University Grossman School of Medicine, New York, NY 10016, United States. Electronic address: myah.draine@nyulangone.org., Gimeli T; Division of Pediatric Pulmonology, The Steven and Alexandra Cohen Children's Medical Center, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Lake Success, NY 11042, United States. Electronic address: tgimeli@northwell.edu., Giusti R; Division of Pediatric Pulmonary Medicine, NYU Langone Health, New York University Grossman School of Medicine, New York, NY 10016, United States. Electronic address: robert.giusti@nyulangone.org., Guzman J; Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, New York, NY 10032, United States. Electronic address: jmg2333@cumc.columbia.edu., Hammouda S; Division of Pediatric Pulmonary Medicine, NYU Langone Health, New York University Grossman School of Medicine, New York, NY 10016, United States. Electronic address: soumia.hammouda@nyulangone.org., Keating C; Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, New York, NY 10032, United States. Electronic address: ck2132@cumc.columbia.edu., Kier C; Department of Pediatrics, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, United States. Electronic address: catherine.kier@stonybrookmedicine.edu., Lennox AT; Division of Pediatric Pulmonology, Allergy, Immunology, and Sleep Medicine, New York Medical College, Valhalla, NY 10595, United States. Electronic address: crl58@cumc.columbia.edu., Liriano C; Division of Pediatric Pulmonology, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, New York, NY 10032, United States. Electronic address: zachary_messser@nymc.edu., Messer Z; Division of Pediatric Pulmonology, Allergy, Immunology, and Sleep Medicine, New York Medical College, Valhalla, NY 10595, United States. Electronic address: alennox@nymc.edu., Plachta A; Division of Pediatric Pulmonology, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel, New York, NY 10003, United States. Electronic address: amy.plachta@mountsinai.org., Sadeghi H; Division of Pediatric Pulmonology, Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons, New York, NY 10032, United States. Electronic address: hs762@cumc.columbia.edu., Schwind E; Division of Pediatric Pulmonology, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel, New York, NY 10003, United States. Electronic address: elinor.schwind@mountsinai.org., Stables-Carney T; Department of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, United States. Electronic address: teresa.stables-carney@stonybrookmedicine.edu., Walker P; Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel, New York, NY 10003, United States. Electronic address: patricia.walker@mountsinai.org., Wang J; Division of Pulmonary, Critical Care and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY 11042, United States. Electronic address: jwang@northwell.edu.
Jazyk: angličtina
Zdroj: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2022 May; Vol. 21 (3), pp. e176-e183. Date of Electronic Publication: 2022 Feb 21.
DOI: 10.1016/j.jcf.2022.02.012
Abstrakt: Background: People with cystic fibrosis (pwCF) may be at risk of complications from COVID-19 but the impact of COVID-19 on pwCF remains unknown.
Methods: We conducted a multicenter retrospective cohort study to assess the impact of the COVID-19 pandemic first wave on pwCF in the New York metropolitan area (NY) from March 1, 2020 to August 31, 2020. Objectives were to determine (1) the prevalence of COVID-19 by PCR and IgG antibody testing, (2) the clinical characteristics of COVID-19, (3) delay in routine outpatient care, and (4) the effect on anxiety and depression in pwCF.
Results: There were 26 COVID-19 cases diagnosed by PCR or antibody testing among the study cohort of 810 pwCF. The prevalence of COVID-19 by PCR (1.6%) and IgG antibody (12.2%) testing was low. 58% of cases were asymptomatic and 82% were managed at home. 8% were hospitalized and 1 person died. 89% of pwCF experienced delay in care. The prevalence of anxiety increased from 43% baseline to 58% during the pandemic (P<0.01). In post-hoc analysis, the proportion of patients with diabetes (38% versus 16%, P<0.01) and pancreatic insufficiency (96% versus 66%, P<0.01) were higher while CFTR modulator use was lower (46% versus 65%, P = 0.05) in pwCF who tested positive for COVID-19.
Conclusions: The prevalence of COVID-19 among pwCF in NY during the pandemic first wave was low and most cases were managed at home. CFTR modulators may be protective. PwCF experienced delay in routine care and increased anxiety.
Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest.
(Copyright © 2022 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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