Branching and converging pathways in fungal natural product biosynthesis.

Autor: Wei X; Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China., Wang WG; Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education and Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Endophytes, State Ethnic Affairs Commission, Yunnan Minzu University, Kunming, 650031, China., Matsuda Y; Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China. ymatsuda@cityu.edu.hk.
Jazyk: angličtina
Zdroj: Fungal biology and biotechnology [Fungal Biol Biotechnol] 2022 Mar 07; Vol. 9 (1), pp. 6. Date of Electronic Publication: 2022 Mar 07.
DOI: 10.1186/s40694-022-00135-w
Abstrakt: In nature, organic molecules with great structural diversity and complexity are synthesized by utilizing a relatively small number of starting materials. A synthetic strategy adopted by nature is pathway branching, in which a common biosynthetic intermediate is transformed into different end products. A natural product can also be synthesized by the fusion of two or more precursors generated from separate metabolic pathways. This review article summarizes several representative branching and converging pathways in fungal natural product biosynthesis to illuminate how fungi are capable of synthesizing a diverse array of natural products.
(© 2022. The Author(s).)
Databáze: MEDLINE
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