Intracellular pH Control by Membrane Transport in Mammalian Cells. Insights Into the Selective Advantages of Functional Redundancy.

Autor:	Doyen D; Université Côte d'Azur, CNRS, Laboratoire de Physiomédecine Moléculaire, Nice, France.; Laboratories of Excellence Ion Channel Science and Therapeutics, Nice, France.; Centre Hospitalier Universitaire de Nice, Service de Médecine Intensive Réanimation, Hôpital Archet 1, Nice, France., Poët M; Université Côte d'Azur, CNRS, Laboratoire de Physiomédecine Moléculaire, Nice, France.; Laboratories of Excellence Ion Channel Science and Therapeutics, Nice, France., Jarretou G; Université Côte d'Azur, CNRS, Laboratoire de Physiomédecine Moléculaire, Nice, France.; Laboratories of Excellence Ion Channel Science and Therapeutics, Nice, France., Pisani DF; Université Côte d'Azur, CNRS, Laboratoire de Physiomédecine Moléculaire, Nice, France.; Laboratories of Excellence Ion Channel Science and Therapeutics, Nice, France., Tauc M; Université Côte d'Azur, CNRS, Laboratoire de Physiomédecine Moléculaire, Nice, France.; Laboratories of Excellence Ion Channel Science and Therapeutics, Nice, France., Cougnon M; Université Côte d'Azur, CNRS, Laboratoire de Physiomédecine Moléculaire, Nice, France.; Laboratories of Excellence Ion Channel Science and Therapeutics, Nice, France., Argentina M; Université Côte d'Azur, CNRS, Institut de Physique de Nice, INPHYNI, Nice, France., Bouret Y; Centre Hospitalier Universitaire de Nice, Service de Médecine Intensive Réanimation, Hôpital Archet 1, Nice, France., Counillon L; Université Côte d'Azur, CNRS, Laboratoire de Physiomédecine Moléculaire, Nice, France.; Laboratories of Excellence Ion Channel Science and Therapeutics, Nice, France.
Jazyk:	angličtina
Zdroj:	Frontiers in molecular biosciences [Front Mol Biosci] 2022 Feb 18; Vol. 9, pp. 825028. Date of Electronic Publication: 2022 Feb 18 (Print Publication: 2022).
DOI:	10.3389/fmolb.2022.825028
Abstrakt:	Intracellular pH is a vital parameter that is maintained close to neutrality in all mammalian cells and tissues and acidic in most intracellular compartments. After presenting the main techniques used for intracellular an vesicular pH measurements we will briefly recall the main molecular mechanisms that affect and regulate intracellular pH. Following this we will discuss the large functional redundancy found in the transporters of H + or acid-base equivalents. For this purpose, we will use mathematical modeling to simulate cellular response to persistent and/or transient acidification, in the presence of different transporters, single or in combination. We will also test the presence or absence of intracellular buffering. This latter section will highlight how modeling can yield fundamental insight into deep biological questions such as the utility of functional redundancy in natural selection. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Doyen, Poët, Jarretou, Pisani, Tauc, Cougnon, Argentina, Bouret and Counillon.)
Databáze:	MEDLINE
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