Genetic Predisposition to Coronavirus Disease 2019 in Relation to Ten Cardiovascular Conditions: A Two-Sample Mendelian Randomization Study.

Autor:	Jia M; Cardiovascular Medicine Department, The Second Hospital of Hebei Medical University, Shijiazhuang, China., Chen HJ; Cardiovascular Medicine Department, The Second Hospital of Hebei Medical University, Shijiazhuang, China., Jia LM; Cardiovascular Medicine Department, The Second Hospital of Hebei Medical University, Shijiazhuang, China., Chen YL; Cardiovascular Medicine Department, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Jazyk:	angličtina
Zdroj:	Frontiers in medicine [Front Med (Lausanne)] 2022 Feb 17; Vol. 9, pp. 796165. Date of Electronic Publication: 2022 Feb 17 (Print Publication: 2022).
DOI:	10.3389/fmed.2022.796165
Abstrakt:	Background: The long-term health consequences of coronavirus disease 2019 (COVID-19) remain largely unclear. This study aimed to apply the Mendelian randomization (MR) design to estimate the causal associations between COVID-19 and ten cardiovascular conditions. Methods: Single-nucleotide polymorphisms (SNPs) associated with COVID-19 were used as instrumental variables to estimate the causal effect of COVID-19 on ten cardiovascular conditions. The random-effects inverse-variance weighted (IVW) method was conducted for the main analyses with a complementary analysis of the weighted median and MR-Egger approaches. Results: In the IVW analysis, genetically predicted COVID-19 was suggestively associated with major coronary heart disease events (OR 1.081; 95% CI 1.007-1.16; P = 0.045) and heart failure (OR 1.049; 95% CI 1.001-1.1; P = 0.045) with similar estimates in weighted median regressions. No directional pleiotropic effects were observed in both funnel plots and MR-Egger intercepts. Conclusions: Our findings provide direct evidence that patients infected with COVID-19 are causally associated with increased risk of cardiovascular disease, especially for major coronary heart disease events and heart failure. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Jia, Chen, Jia and Chen.)
Databáze:	MEDLINE
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