Re-positive testing, clinical evolution and clearance of infection: results from COVID-19 cases in isolation in Viet Nam.

Autor:	Hoang NA; Department of Epidemiology, National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam.; National Centre for Epidemiology and Population Health, Research School of Population Health, College of Health and Medicine, Australian National University, Canberra, Australia.; These authors contributed equally., Pham TQ; Department of Epidemiology, National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam.; School of Preventive Medicine and Public Health, Hanoi Medical University, Hanoi, Viet Nam.; These authors contributed equally., Quach HL; Department of Epidemiology, National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam.; National Centre for Epidemiology and Population Health, Research School of Population Health, College of Health and Medicine, Australian National University, Canberra, Australia., Nguyen KC; Department of Epidemiology, National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Colquhoun S; National Centre for Epidemiology and Population Health, Research School of Population Health, College of Health and Medicine, Australian National University, Canberra, Australia., Lambert S; National Centre for Epidemiology and Population Health, Research School of Population Health, College of Health and Medicine, Australian National University, Canberra, Australia., Luong DH; Department of Epidemiology, National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Tran QD; General Department of Preventive Medicine, Ministry of Health, Hanoi, Viet Nam., Phung DC; National Agency for Science and Technology Information, Ministry of Science and Technology, Viet Nam., Duong TN; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Ngu ND; Department of Epidemiology, National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Tran TA; Department of Epidemiology, National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Nguyen HBT; National Hospital of Tropical Diseases, Hanoi, Viet Nam., Dang DA; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam.; These authors contributed equally., Vogt F; National Centre for Epidemiology and Population Health, Research School of Population Health, College of Health and Medicine, Australian National University, Canberra, Australia.; The Kirby Institute, University of New South Wales, Sydney, NSW, Australia.; These authors contributed equally.
Jazyk:	angličtina
Zdroj:	Western Pacific surveillance and response journal : WPSAR [Western Pac Surveill Response J] 2021 Dec 13; Vol. 12 (4), pp. 1-11. Date of Electronic Publication: 2021 Dec 13 (Print Publication: 2021).
DOI:	10.5365/wpsar.2021.12.4.857
Abstrakt:	Objective: Asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and test re-positivity after a negative test have raised concerns about the ability to effectively control the coronavirus disease 2019 (COVID-19) pandemic. We aimed to investigate the prevalence of COVID-19 asymptomatic and pre-symptomatic infections during the second wave of COVID-19 in Viet Nam, and to better understand the duration of SARS-CoV-2 infection and the dynamics between the evolution of clinical symptoms and SARS-CoV-2 test positivity among confirmed COVID-19 cases. Methods: We conducted a cohort analysis on the first 50 confirmed cases during the second COVID-19 wave in Viet Nam using clinical, laboratory and epidemiological data collected from 9 March to 30 April 2020. Kaplan-Meier estimates were used to assess time to clearance of SARS-CoV-2 infection, and log-rank tests were used to explore factors related to time to SARS-CoV-2 infection clearance. Results: Most cases (58%) had no typical signs or symptoms of COVID-19 at the time of diagnosis. Ten cases (20%) were re-positive for SARS-CoV-2 during infection. Eight cases (16%) experienced COVID-19 symptoms after testing negative for SARS-CoV-2. The median duration from symptom onset until clearance of infection was 14 days (range: 6-31); it was longer in re-positive and older patients and those with pre-existing conditions. Conclusion: Asymptomatic and pre-symptomatic infections were common during the second wave of COVID-19 in Viet Nam. Re-positivity was frequent during hospitalization and led to a long duration of SARS-CoV-2 infection. ((c) 2021 The authors; licensee World Health Organization.)
Databáze:	MEDLINE
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