Tissue Engineering Strategies for Retina Regeneration.

Autor:	Nair DSR; Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Seiler MJ; Departments of Physical Medicine & Rehabilitation, Ophthalmology, Anatomy & Neurobiology, Sue and Bill Gross Stem Cell Research Centre, University of California, Irvine, CA 92697-1705, USA., Patel KH; Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Thomas V; Department of Physics, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Camarillo JCM; Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA 90033, USA., Humayun MS; Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA 90033, USA., Thomas BB; Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA 90033, USA.
Jazyk:	angličtina
Zdroj:	Applied sciences (Basel, Switzerland) [Appl Sci (Basel)] 2021 Mar; Vol. 11 (5). Date of Electronic Publication: 2021 Feb 28.
DOI:	10.3390/app11052154
Abstrakt:	The retina is a complex and fragile photosensitive part of the central nervous system which is prone to degenerative diseases leading to permanent vision loss. No proven treatment strategies exist to treat or reverse the degenerative conditions. Recent investigations demonstrate that cell transplantation therapies to replace the dysfunctional retinal pigment epithelial (RPE) cells and or the degenerating photoreceptors (PRs) are viable options to restore vision. Pluripotent stem cells, retinal progenitor cells, and somatic stem cells are the main cell sources used for cell transplantation therapies. The success of retinal transplantation based on cell suspension injection is hindered by limited cell survival and lack of cellular integration. Recent advances in material science helped to develop strategies to grow cells as intact monolayers or as sheets on biomaterial scaffolds for transplantation into the eyes. Such implants are found to be more promising than the bolus injection approach. Tissue engineering techniques are specifically designed to construct biodegradable or non-degradable polymer scaffolds to grow cells as a monolayer and construct implantable grafts. The engineered cell construct along with the extracellular matrix formed, can hold the cells in place to enable easy survival, better integration, and improved visual function. This article reviews the advances in the use of scaffolds for transplantation studies in animal models and their application in current clinical trials. Competing Interests: Conflicts of Interest: The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
Databáze:	MEDLINE
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