Effect and Mechanisms of Quercetin for Experimental Focal Cerebral Ischemia: A Systematic Review and Meta-Analysis.

Autor: Guo C; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Wang WJ; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Liao YC; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Zhao C; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Yin Y; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Yao MN; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Ding Y; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China., Wang JW; Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Jazyk: angličtina
Zdroj: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2022 Feb 25; Vol. 2022, pp. 9749461. Date of Electronic Publication: 2022 Feb 25 (Print Publication: 2022).
DOI: 10.1155/2022/9749461
Abstrakt: Quercetin, a naturally occurring flavonoid, is mainly extracted from tea, onions, and apples. It has the underlying neuroprotective effect on experimental ischemic stroke. A systematic review and meta-analysis were used to assess quercetin's efficacy and possible mechanisms in treating focal cerebral ischemia. Compared with the control group, twelve studies reported a remarkable function of quercetin in improving the neurological function score (NFS) ( P < 0.05), and twelve studies reported a significant effect on reducing infarct volume ( P < 0.05). Moreover, two and three studies showed that quercetin could alleviate blood-brain barrier (BBB) permeability and brain water content, respectively. The mechanisms of quercetin against focal cerebral ischemia are diverse, involving antioxidation, antiapoptotic, anti-inflammation, and calcium overload reduction. On the whole, the present study suggested that quercetin can exert a protective effect on experimental ischemic stroke. Although the effect size may be overestimated because of the quality of studies and possible publication bias, these results indicated that quercetin might be a promising neuroprotective agent for human ischemic stroke. This study is registered with PROSPERO, number CRD 42021275656.
Competing Interests: The authors claim that the present study was conducted without any business or financial relationships that could be interpreted as potential conflicts of interest.
(Copyright © 2022 Chao Guo et al.)
Databáze: MEDLINE
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