Case Report: True Motor Recovery of Upper Limb Beyond 5 Years Post-stroke.

Autor:	Ciceron C; Service de Médecine Physique et Réadaptation, Plateforme Mouvement et Handicap, Hôpital Henry Gabrielle, Hospices Civils de Lyon, Pierre-Bénite, France.; CRNL (Lyon Neuroscience Research Center, Trajectoires Team), INSERM U1028 & CNRS UMR 5292, Université Claude Bernard-Lyon 1, Bron, France., Sappey-Marinier D; CREATIS, CNRS UMR 5220 & INSERM U1294, Université Claude Bernard-Lyon1, INSA de Lyon, Université de Lyon, Villeurbanne, France.; CERMEP-Imagerie du Vivant, Université de Lyon, Bron, France., Riffo P; Service de Médecine Physique et Réadaptation, Plateforme Mouvement et Handicap, Hôpital Henry Gabrielle, Hospices Civils de Lyon, Pierre-Bénite, France., Bellaiche S; Service de Médecine Physique et Réadaptation, Plateforme Mouvement et Handicap, Hôpital Henry Gabrielle, Hospices Civils de Lyon, Pierre-Bénite, France., Kocevar G; CREATIS, CNRS UMR 5220 & INSERM U1294, Université Claude Bernard-Lyon1, INSA de Lyon, Université de Lyon, Villeurbanne, France., Hannoun S; CREATIS, CNRS UMR 5220 & INSERM U1294, Université Claude Bernard-Lyon1, INSA de Lyon, Université de Lyon, Villeurbanne, France.; Medical Imaging Sciences Program, Division of Health Professions, Faculty of Health Sciences, American University of Beirut, Beirut, Lebanon., Stamile C; CREATIS, CNRS UMR 5220 & INSERM U1294, Université Claude Bernard-Lyon1, INSA de Lyon, Université de Lyon, Villeurbanne, France., Redoute J; CERMEP-Imagerie du Vivant, Université de Lyon, Bron, France., Cotton F; CREATIS, CNRS UMR 5220 & INSERM U1294, Université Claude Bernard-Lyon1, INSA de Lyon, Université de Lyon, Villeurbanne, France.; Service de Radiologie, Center Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre-Bénite, France., Revol P; Service de Médecine Physique et Réadaptation, Plateforme Mouvement et Handicap, Hôpital Henry Gabrielle, Hospices Civils de Lyon, Pierre-Bénite, France.; CRNL (Lyon Neuroscience Research Center, Trajectoires Team), INSERM U1028 & CNRS UMR 5292, Université Claude Bernard-Lyon 1, Bron, France., Andre-Obadia N; Service de Neurologie Fonctionnelle et Epileptologie, Hôpital Pierre Wertheimer, Hospices Civils de Lyon, Bron, France.; CRNL (Lyon Neuroscience Research Center, NeuroPain Team), INSERM U1028 & CNRS UMR 5292, University Claude Bernard-Lyon 1, Bron, France., Luaute J; Service de Médecine Physique et Réadaptation, Plateforme Mouvement et Handicap, Hôpital Henry Gabrielle, Hospices Civils de Lyon, Pierre-Bénite, France.; CRNL (Lyon Neuroscience Research Center, Trajectoires Team), INSERM U1028 & CNRS UMR 5292, Université Claude Bernard-Lyon 1, Bron, France., Rode G; Service de Médecine Physique et Réadaptation, Plateforme Mouvement et Handicap, Hôpital Henry Gabrielle, Hospices Civils de Lyon, Pierre-Bénite, France.; CRNL (Lyon Neuroscience Research Center, Trajectoires Team), INSERM U1028 & CNRS UMR 5292, Université Claude Bernard-Lyon 1, Bron, France.
Jazyk:	angličtina
Zdroj:	Frontiers in neurology [Front Neurol] 2022 Feb 17; Vol. 13, pp. 804528. Date of Electronic Publication: 2022 Feb 17 (Print Publication: 2022).
DOI:	10.3389/fneur.2022.804528
Abstrakt:	Most of motor recovery usually occurs within the first 3 months after stroke. Herein is reported a remarkable late recovery of the right upper-limb motor function after a left middle cerebral artery stroke. This recovery happened progressively, from two to 12 years post-stroke onset, and along a proximo-distal gradient, including dissociated finger movements after 5 years. Standardized clinical assessment and quantified analysis of the reach-to-grasp movement were repeated over time to characterize the recovery. Twelve years after stroke onset, diffusion tensor imaging (DTI), functional magnetic resonance imaging (fMRI), and transcranial magnetic stimulation (TMS) analyses of the corticospinal tracts were carried out to investigate the plasticity mechanisms and efferent pathways underlying motor control of the paretic hand. Clinical evaluations and quantified movement analysis argue for a true neurological recovery rather than a compensation mechanism. DTI showed a significant decrease of fractional anisotropy, associated with a severe atrophy, only in the upper part of the left corticospinal tract (CST), suggesting an alteration of the CST at the level of the infarction that is not propagated downstream. The finger opposition movement of the right paretic hand was associated with fMRI activations of a broad network including predominantly the contralateral sensorimotor areas. Motor evoked potentials were normal and the selective stimulation of the right hemisphere did not elicit any response of the ipsilateral upper limb. These findings support the idea that the motor control of the paretic hand is mediated mainly by the contralateral sensorimotor cortex and the corresponding CST, but also by a plasticity of motor-related areas in both hemispheres. To our knowledge, this is the first report of a high quality upper-limb recovery occurring more than 2 years after stroke with a genuine insight of brain plasticity mechanisms. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Ciceron, Sappey-Marinier, Riffo, Bellaiche, Kocevar, Hannoun, Stamile, Redoute, Cotton, Revol, Andre-Obadia, Luaute and Rode.)
Databáze:	MEDLINE
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