Eco-Friendly Synthesis of MnO 2 Nanorods Using Gmelina arborea Fruit Extract and Its Anticancer Potency Against MCF-7 Breast Cancer Cell Line.

Autor: Srinivasa C; Department of Studies in Biotechnology, Davangere University, Davangere, 577 007, Karnataka, India., Kumar SRS; Department of Studies in Food Technology, Davangere University, Davangere, 577 007, Karnataka, India., Pradeep S; Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, Karnataka, 570 015, India., Prasad SK; Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, Karnataka, 570 015, India., Veerapur R; Department of Metallurgy and Materials Engineering, Malawi Institute of Technology, Malawi University of Science and Technology, Limbe, Malawi., Ansari MA; Department of Epidemic Disease Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, 31441, Saudi Arabia., Alomary MN; National Centre for Biotechnology, King Abdulaziz City for Science and Technology (KACST), Riyadh, 11442, Saudi Arabia., Alghamdi S; Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, 24231, Saudi Arabia., Almehmadi M; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, 21944, Saudi Arabia., Gc K; Department of Studies in Biotechnology, Davangere University, Davangere, 577 007, Karnataka, India., Daphedar AB; Department of Studies in Botany, Anjuman Arts, Science and Commerce College, Vijayapura, Karnataka, 586 101, India., Kakkalameli SB; Department of Studies in Botany, Davangere University, Davangere, 577 007, Karnataka, India., Shivamallu C; Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, Karnataka, 570 015, India., Kollur SP; Department of Sciences, Amrita School of Arts and Sciences, Amrita Vishwa Vidyapeetham, Mysuru Campus, Mysuru, Karnataka, 570 026, India.; School of Agriculture, Geography, Environment, Ocean and Natural Sciences (SAGEONS), The University of the South Pacific, Suva, Fiji.
Jazyk: angličtina
Zdroj: International journal of nanomedicine [Int J Nanomedicine] 2022 Feb 25; Vol. 17, pp. 901-907. Date of Electronic Publication: 2022 Feb 25 (Print Publication: 2022).
DOI: 10.2147/IJN.S335848
Abstrakt: Introduction: Cancer disease is known due to its unregulated proliferation of cells that have evolved from the body's regular cells. The disease develops as a result of epigenetic and genetic modifications, tumor suppressor gene inactivation, and oncogene activation. The present work describes an environmentally benign approach for the synthesis of manganese oxide nanoparticles (MnO 2 NPs) using Gmelina arborea fruit extract (GAE) in an aqueous medium.
Methods: The study evaluated the formation of MnO 2 NPs and their anticancer efficacy against MCF-7 breast cancer cell line.
Results: The formation of MnO 2 NPs was confirmed through powder X-ray diffractometer (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and high-resolution transmission electron microscopy (HR-TEM). The crystalline nature of as-prepared MnO 2 NPs was evident from XRD pattern. The morphology of the material was studied using SEM analysis, which suggested a rod-like nature with an average diameter of 50 nm. Further, the TEM and HR-TEM images confirmed the rod shape of the as-prepared MnO2 NPs with an interplanar distance of 0.271 nm. In addition, the concentric rings from selected area electron diffraction (SAED) analysis show the crystalline nature of the as-prepared material, which further supports the obtained XRD pattern. The anticancer efficacy of MnO 2 NPs was evaluated against MCF-7 breast cancer cell line, which showed up to 96% inhibition of the cells at 400 µg/mL concentration.
Conclusion: Bio-conjugation of MnO 2 NPs can provide enough scope for the therapeutic use of Gmelina arborea , assuming appropriate mechanistic evaluations are conducted.
Competing Interests: The authors declare that there are no conflicts of interest.
(© 2022 Srinivasa et al.)
Databáze: MEDLINE
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