Latest Insights on the Diagnostic Approaches and Treatment Strategies of COVID-19.

Autor:	Hassanein SS; Basic and Applied Sciences (BAS) Institute, Biotechnology Program, Egypt-Japan University of Science and Technology (E-JUST), Alexandria, Egypt.; Zoology Department, Faculty of Science, Cairo University, Giza, Egypt., Sharaby MR; Basic and Applied Sciences (BAS) Institute, Biotechnology Program, Egypt-Japan University of Science and Technology (E-JUST), Alexandria, Egypt.; Botany and Microbiology Department, Faculty of Science, Alexandria University, Alexandria, Egypt., Tawfik NM; Basic and Applied Sciences (BAS) Institute, Biotechnology Program, Egypt-Japan University of Science and Technology (E-JUST), Alexandria, Egypt.; Zoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt., Rashed SA; Basic and Applied Sciences (BAS) Institute, Biotechnology Program, Egypt-Japan University of Science and Technology (E-JUST), Alexandria, Egypt.; Botany and Microbiology Department, Faculty of Science, Alexandria University, Alexandria, Egypt., Adel M; Basic and Applied Sciences (BAS) Institute, Biotechnology Program, Egypt-Japan University of Science and Technology (E-JUST), Alexandria, Egypt.; Botany and Microbiology Department, Faculty of Science, Helwan University, Cairo, Egypt., Fayez A; Basic and Applied Sciences (BAS) Institute, Biotechnology Program, Egypt-Japan University of Science and Technology (E-JUST), Alexandria, Egypt., Mansour H; Basic and Applied Sciences (BAS) Institute, Biotechnology Program, Egypt-Japan University of Science and Technology (E-JUST), Alexandria, Egypt.; Polymeric Materials Research Department, Advanced Technology and New Materials Research Institute, City of Scientific Research and Technological Applications, Alexandria, Egypt., Amer HM; Virology Department, Faculty of Medicine Veterinary, Cairo University, Giza, Egypt.
Jazyk:	angličtina
Zdroj:	Intervirology [Intervirology] 2022; Vol. 65 (4), pp. 167-180. Date of Electronic Publication: 2022 Mar 04.
DOI:	10.1159/000522336
Abstrakt:	Background: COVID-19 has emerged as the most serious pandemic in the 21st century to date. COVID-19 patients may develop various disease symptoms that hinder the accurate clinical diagnosis. Summary: Routine diagnosis of COVID-19 requires complementary investigations, including computed tomography, immunological assays, and molecular assays like real-time RT-PCR, loop-mediated isothermal amplification, metagenomic next-generation sequencing, and clusters of regularly interspaced short palindromic repeats-based assays. Clinically approved antiviral drugs available for the COVID-19 treatment are very limited. The most common measurements that enhance health condition and patients' viability are conservation fluid management, oxygen therapy, and antibiotics. Several therapeutic options have been developed or repurposed to prevent virus replication and/or modulate the immune response against virus infection. These options include various drugs that affect virus entry and membrane fusion, inhibit polymerase and protease activity, suppress the host pro-inflammatory cytokines, and utilize cell therapy approaches. Key Messages: In this review, we aimed to provide an up-to-date discussion on the current diagnostic options and therapeutic strategies used to control and manage COVID-19 in clinical and point-of-care settings. (© 2022 The Author(s). Published by S. Karger AG, Basel.)
Databáze:	MEDLINE
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