Association between sleep-disordered breathing and prostate cancer.

Autor: Campos-Rodriguez F; Respiratory Department, Hospital Universitario de Valme, Sevilla, Spain; Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain. Electronic address: fracamrod@gmail.com., Santos-Morano J; Respiratory Department, Hospital Universitario de Valme, Sevilla, Spain., Jurado-Gamez B; Respiratory Department, Hospital Universitario Reina Sofía, Córdoba, Spain; Instituto de Investigación Biomédica Maimonides (IMIBIC), Universidad de Córdoba, Spain., Osman-Garcia I; Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain; Urology and Nephrology Department, Hospital Universitario Virgen del Rocío, Sevilla, Spain., Rivera-Muñoz F; Urology Department, Hospital Universitario de Valme, Sevilla, Spain., Salguero J; Urology Department, Hospital Universitario Reina Sofía, Córdoba, Spain., Mañas-Escorza PM; Sleep-Disordered Breathing Unit, Hospital Universitario Virgen del Rocío, Sevilla, Spain., Almeida-Gonzalez CV; Biostatistics Unit, Hospital Universitario de Valme, Sevilla, Spain.
Jazyk: angličtina
Zdroj: Sleep medicine [Sleep Med] 2022 Mar; Vol. 91, pp. 35-42. Date of Electronic Publication: 2022 Feb 16.
DOI: 10.1016/j.sleep.2022.02.007
Abstrakt: Background: Sleep-disordered breathing (SDB) has been associated with a greater aggressiveness of melanoma tumors, but the association with other cancers is unknown. This study investigates the relationship between the severity of SDB and the aggressiveness of prostate cancer (PC).
Methods: 165 patients under 66 years consecutively diagnosed with PC in three University Hospitals underwent a home respiratory polygraphy. SDB severity was assessed by means of the apnea-hypopnea index (AHI) as well as several oximetric parameters. The primary marker of the aggressiveness of PC was the Gleason score, while secondary markers included the tumor stage and metastatic spreading.
Results: The patients had a median (P 25-75) age of 60 (56-63) years, AHI of 13.3 (5.7-25.8), and 4% oxygen desaturation index of 8.7 (2.9-17.8). The prevalence of an AHI≥5 and AHI≥15 was 78.2% and 46.7%, respectively. The median AHI was similar in patients with Gleason 6 and > 6 [13.7 (5.6-28.7) vs 12.2 (5.7-23.2), p = 0.44], tumor stage I-II and III-IV [13.5 (5.3-26.5) vs 11.7 (7.8-21.1), p = 0.67], and presence or absence of metastasis [14.2 (9.6-31.8) vs 13.3 (5.2-24.6), p = 0.46]. The prevalence of an AHI≥5 and AHI≥15 was similar in patients with Gleason 6 and > 6 (79.2% vs 77.2%; p = 0.85, and 49.3% vs 44.33%; p = 0.53, respectively). These results did not change when different oximetric variables were analyzed instead of the AHI.
Conclusions: Despite the high prevalence of SDB in patients with PC, our results do not support any association between the severity of SDB and PC aggressiveness.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: