Primary intracranial melanoma, amelanotic variant: Case report.

Autor: Andrés Sanz JA; Servicio de Neurocirugía, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain; Instituto de investigación Sanitaria de Aragón (IISA), Spain. Electronic address: julioalberto512@gmail.com., Ruiz Ginés JA; Servicio de Neurocirugía, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain; Instituto de investigación Sanitaria de Aragón (IISA), Spain., Iliev H; Servicio de Anatomía Patológica, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain., Aguas Valiente J; Servicio de Neurocirugía, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain; Instituto de investigación Sanitaria de Aragón (IISA), Spain.
Jazyk: angličtina
Zdroj: Neurocirugia (English Edition) [Neurocirugia (Astur : Engl Ed)] 2022 Nov-Dec; Vol. 33 (6), pp. 383-388. Date of Electronic Publication: 2022 Mar 02.
DOI: 10.1016/j.neucie.2022.02.005
Abstrakt: Primary brain melanoma is a very rare tumour (only 0.07% of primary CNS neoplasms) which usually shows with abundant melanin content; whereas hypo/melanotic variants have been scarcely described. We introduce the case of a female patient with headache, left brachial paresis and frontallobar syndrome. The MRI image showed a right frontal mass with homogeneous contrast uptake. As treatment, a complete surgical resection was performed. Pathology was diagnostic for melanoma, with very low melanin content and a high proliferative index. A thorough extension study was performed to rule out an extracranial primary origin. Due to several intercurrent complications, the patient evolved unfavorably, not being able to receive further treatment. The amelanotic variant of primary intracranial malignant melanomas has not been described in detail previously. We will review the literature, focusing on the particularities of management and diagnosis of this clinical entity.
(Copyright © 2022. Published by Elsevier España, S.L.U.)
Databáze: MEDLINE
Externí odkaz: