Real-life consequences of cognitive dysfunction in Parkinson's disease.

Autor:	Kay KR; Department of Neurology, University of Iowa, Iowa City, IA, United States; Neurology Service, Veterans Affairs Medical Center, Iowa City, IA, United States., Uc EY; Department of Neurology, University of Iowa, Iowa City, IA, United States; Neurology Service, Veterans Affairs Medical Center, Iowa City, IA, United States. Electronic address: ergun-uc@uiowa.edu.
Jazyk:	angličtina
Zdroj:	Progress in brain research [Prog Brain Res] 2022; Vol. 269 (1), pp. 113-136. Date of Electronic Publication: 2022 Feb 08.
DOI:	10.1016/bs.pbr.2022.01.005
Abstrakt:	While motor symptoms are the most recognized features of Parkinson's disease (PD), cognitive dysfunction is a key determinant of consequences of PD in real-life. In this chapter we review important domains where cognitive dysfunction negatively impacts the lives of people with PD (PwPD), such as difficulties in occupational and social life, and instrumental ADLs such as driving. Early loss of employment has important effects for PwPD, their families, and society. PwPD experience higher rates of family and social discord as well as important changes in their social roles. These processes are largely mediated through cognitive dysfunction, particularly difficulties processing and understanding emotions, decreased attention, and executive dysfunction. Cognitive dysfunction is also an important mediator of driving impairments, which contributes to decreased independence in PwPD. Finally, we briefly review the costs associated with cognitive impairment in PD. Both indirect and direct costs for PwPD with cognitive impairment are substantially higher than for PwPD with normal cognition. (Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu