Adult-Attained Height and Colorectal Cancer Risk: A Cohort Study, Systematic Review, and Meta-Analysis.

Autor:	Zhou E; Department of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Institute for Digestive Health and Liver Disease, Mercy Medical Center, Baltimore, Maryland., Wang L; Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland., Santiago CN; Johns Hopkins University School of Medicine, Baltimore, Maryland., Nanavati J; Johns Hopkins University School of Medicine, Baltimore, Maryland., Rifkin S; Department of Gastroenterology and Hepatology, Internal Medicine, University of Michigan, Ann Arbor, Michigan., Spence E; Johns Hopkins University School of Medicine, Baltimore, Maryland., Hylind LM; Department of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Gills JJ; Johns Hopkins University School of Medicine, Baltimore, Maryland., La Luna L; Digestive Disease Associates, Ltd, Wyomissing, Pennsylvania., Kafonek DR; Department of Gastroenterology and Hepatology at Green Spring Station Endoscopy Center, Johns Hopkins Health Care & Surgery Center, Lutherville, Maryland., Cromwell DM; Department of Gastroenterology and Hepatology at Green Spring Station Endoscopy Center, Johns Hopkins Health Care & Surgery Center, Lutherville, Maryland., Drewes JL; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Sears CL; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland., Giardiello FM; Department of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Mullin GE; Department of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jazyk:	angličtina
Zdroj:	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2022 Apr 01; Vol. 31 (4), pp. 783-792.
DOI:	10.1158/1055-9965.EPI-21-0398
Abstrakt:	Background: The influence of anthropometric characteristics on colorectal neoplasia biology is unclear. We conducted a systematic review and meta-analysis to determine if adult-attained height is independently associated with the risk of colorectal cancer or adenoma. Methods: We searched MEDLINE, EMBASE, the Cochrane Library, and Web of Science from inception to August 2020 for studies on the association between adult-attained height and colorectal cancer or adenoma. The original data from the Johns Hopkins (Baltimore, MD) Colon Biofilm study was also included. The overall HR/OR of colorectal cancer/adenoma with increased height was estimated using random-effects meta-analysis. Results: We included 47 observational studies involving 280,644 colorectal cancer and 14,139 colorectal adenoma cases. Thirty-three studies reported data for colorectal cancer incidence per 10-cm increase in height; 19 yielded an HR of 1.14 [95% confidence interval (CI), 1.11-1.17; P < 0.001), and 14 engendered an OR of 1.09 (95% CI, 1.05-1.13; P < 0.001). Twenty-six studies compared colorectal cancer incidence between individuals within the highest versus the lowest height percentile; 19 indicated an HR of 1.24 (95% CI, 1.19-1.30; P < 0.001), and seven resulting in an OR of 1.07 (95% CI, 0.92-1.25; P = 0.39). Four studies reported data for assessing colorectal adenoma incidence per 10-cm increase in height, showing an overall OR of 1.06 (95% CI, 1.00-1.12; P = 0.03). Conclusions: Greater adult attained height is associated with an increased risk of colorectal cancer and adenoma. Impact: Height should be considered as a risk factor for colorectal cancer screening. (©2022 American Association for Cancer Research.)
Databáze:	MEDLINE
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