Myoglobin: From physiological roles to potential implications in cancer.

Autor: Elkholi IE; Center for Aging and Associated Diseases (CAAD), Zewail City of Science, Technology, and Innovation, 6th of October City, Giza 12578, Egypt; Montreal Clinical Research Institute (IRCM), Montréal, QC H2W 1R7, Canada; Molecular Biology Programs, Université de Montréal, Montréal, QC H3T 1J4, Canada., Elsherbiny ME; Department of Pharmacology and Toxicology, Ahram Canadian University, 6th of October City, Giza, Egypt., Emara M; Center for Aging and Associated Diseases (CAAD), Zewail City of Science, Technology, and Innovation, 6th of October City, Giza 12578, Egypt. Electronic address: memara@zewailcity.edu.eg.
Jazyk: angličtina
Zdroj: Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2022 May; Vol. 1877 (3), pp. 188706. Date of Electronic Publication: 2022 Mar 02.
DOI: 10.1016/j.bbcan.2022.188706
Abstrakt: Myoglobin (MB) belongs to the well-studied globin proteins superfamily. It has been extensively studied for its physiological roles in oxygen storage and transport for about a century now. However, the last two decades shed the light on unexpected aspects for MB research. Myoglobin has been suggested as a scavenger for nitric oxide and reactive oxygen species (ROS). Furthermore, MB was found to be expressed and regulated in different tissues, beyond the muscle lineage, including cancers. Current evidence suggest that MB is directly regulated by hypoxia and might be contributing to the metabolic rewiring in cancer tissues. In this article, we first discuss the MB physiological roles and then focus on the latter potential roles and regulatory networks of MB in cancer.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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