Risk factors for placental human papillomavirus infection.

Autor:	Niyibizi J; Department of Social and Preventive Medicine, Université de Montréal, Montreal, Quebec, Canada.; Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada., Mayrand MH; Department of Obstetrics and Gynecology, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec, Canada.; Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada., Audibert F; Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montreal, Quebec, Canada., Monnier P; Department of Obstetrics and Gynecology, McGill University and Research Institute of the McGill University Health Center, Montreal, Canada, Montreal, Quebec, Canada., Brassard P; Division of Clinical Epidemiology, McGill University Health Center, McGill University, Montreal, Quebec, Canada., Laporte L; Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada., Lacaille J; Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada., Zahreddine M; Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada., Bédard MJ; Department of Obstetrics and Gynecology, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec, Canada., Girard I; Department of Obstetrics and Gynecology, St-Mary's Hospital Center, Montreal, Quebec, Canada., Francoeur D; Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montreal, Quebec, Canada., Carceller AM; Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montreal, Quebec, Canada., Lacroix J; Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montreal, Quebec, Canada., Fraser W; Department of Obstetrics and Gynecology, Centre de recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS), Université de Sherbrooke, Sherbrooke, Quebec, Canada., Coutlée F; Département de microbiologie, infectiologie et immunologie, Université de Montréal, Montreal, Quebec, Canada.; Départements de clinique de Médecine de laboratoire et de Médecine, Services de biologie moléculaire et d'infectiologie, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec, Canada., Trottier H; Department of Social and Preventive Medicine, Université de Montréal, Montreal, Quebec, Canada helen.trottier@umontreal.ca.; Centre de Recherche du Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada.
Jazyk:	angličtina
Zdroj:	Sexually transmitted infections [Sex Transm Infect] 2022 Dec; Vol. 98 (8), pp. 575-581. Date of Electronic Publication: 2022 Mar 04.
DOI:	10.1136/sextrans-2021-055172
Abstrakt:	Objective: Human papillomavirus (HPV) has been associated with adverse pregnancy outcomes but placental HPV infection has been rarely studied. The objective was to determine the proportion of HPV-positive placentas and the associated risk factors among HPV-positive women during pregnancy. Methods: We analysed data from pregnant women enrolled in HERITAGE cohort study between 2010 and 2016 with positive vaginal HPV infection during the first trimester of pregnancy (n=354). Placental swabs and biopsies were collected. HPV genotyping was performed using Linear Array. The predictors of placental HPV detection were identified by generalised estimating equations models. Results: HPV was detected in 78 placentas (22.0%) (one among 96 caesarean sections and 77 among 258 vaginal deliveries). Overall, 91% of HPV-positive placentas were positive for a genotype that was detected in vaginal samples during pregnancy. Among women who delivered vaginally, abnormal cytology (adjusted OR (aOR) 1.78 (95% CI 1.02 to 3.10)), other genitourinary infection (aOR 2.41 (95% CI 1.31 to 4.44)), presence of multiple HPV genotypes in the first trimester (aOR 2.69 (95% CI 1.76 to 4.12)) and persistence of high-risk HPV infections during pregnancy (HPV-16/18: aOR 3.94 (95% CI 2.06 to 7.55) and other than HPV-16/18: aOR 2.06 (95% CI 1.05 to 4.02)) were independently associated with placental HPV. Conclusions: HPV was frequently detected in the placenta of women who delivered vaginally and may be associated with host immune response characteristics. Competing Interests: Competing interests: FC has received grants to evaluate HPV detection tests through his institution from Becton-Dickson and Roche Molecular systems. HT has received occasional lecture fees from Merck and unrestricted grants form ViiV Healthcare. All other coauthors have no conflict of interests. (© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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