Transitional premonocytes emerge in the periphery for host defense against bacterial infections.

Autor:	Teh YC; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore.; Department of Biological Science, National University of Singapore (NUS), Singapore 117543, Singapore., Chooi MY; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore., Liu D; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore., Kwok I; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore., Lai GC; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore., Ayub Ow Yong L; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.; Genome Institute of Singapore, A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138672, Singapore., Ng M; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore., Li JLY; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore., Tan Y; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore.; National Skin Centre, 1 Mandalay Road, Singapore 308205, Singapore., Evrard M; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore., Tan L; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore., Liong KH; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore., Leong K; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore., Goh CC; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore., Chan AYJ; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore., Shadan NB; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore., Mantri CK; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore., Hwang YY; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore., Cheng H; State Key Laboratory of Experimental Hematology, National Clinical Research Centre for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China., Cheng T; State Key Laboratory of Experimental Hematology, National Clinical Research Centre for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China., Yu W; Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore 138673, Singapore., Tey HL; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.; National Skin Centre, 1 Mandalay Road, Singapore 308205, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore., Larbi A; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore., St John A; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore., Angeli V; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore., Ruedl C; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Lee B; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore., Ginhoux F; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore.; Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai 200025, China., Chen SL; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.; Genome Institute of Singapore, A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138672, Singapore., Ng LG; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.; State Key Laboratory of Experimental Hematology, National Clinical Research Centre for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Ding JL; Department of Biological Science, National University of Singapore (NUS), Singapore 117543, Singapore., Chong SZ; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore 138648, Singapore.
Jazyk:	angličtina
Zdroj:	Science advances [Sci Adv] 2022 Mar 04; Vol. 8 (9), pp. eabj4641. Date of Electronic Publication: 2022 Mar 04.
DOI:	10.1126/sciadv.abj4641
Abstrakt:	Circulating Ly6C hi monocytes often undergo cellular death upon exhaustion of their antibacterial effector functions, which limits their capacity for subsequent macrophage differentiation. This shrouds the understanding on how the host replaces the tissue-resident macrophage niche effectively during bacterial invasion to avert infection morbidity. Here, we show that proliferating transitional premonocytes (TpMos), an immediate precursor of mature Ly6C hi monocytes (MatMos), were mobilized into the periphery in response to acute bacterial infection and sepsis. TpMos were less susceptible to apoptosis and served as the main source of macrophage replenishment when MatMos were vulnerable toward bacteria-induced cellular death. Furthermore, TpMo and its derived macrophages contributed to host defense by balancing the proinflammatory cytokine response of MatMos. Consequently, adoptive transfer of TpMos improved the survival outcome of lethal sepsis. Our findings hence highlight a protective role for TpMos during bacterial infections and their contribution toward monocyte-derived macrophage heterogeneity in distinct disease outcomes.
Databáze:	MEDLINE
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