Radiotherapy-related toxicity for localized prostate cancer: meta-analysis comparing conventional or moderately hypofractionated vs. ultrahypofractionated protocols.

Autor: Baccaglini W; Department of Urology, Faculdade de Medicina Do ABC, Santo André, São Paulo, Brazil. wbaccaglini@gmail.com.; Department of Urology, Albert Einstein Israelite Hospital, São Paulo, São Paulo, Brazil. wbaccaglini@gmail.com., de Carvalho IT; Department of Radiation Oncology, Albert Einstein Israelite Hospital, São Paulo, São Paulo, Brazil., Glina FPA; Department of Urology, Faculdade de Medicina Do ABC, Santo André, São Paulo, Brazil., Pazeto CL; Department of Urology, Faculdade de Medicina Do ABC, Santo André, São Paulo, Brazil., Marantes A; Department of Urology, Faculdade de Medicina Do ABC, Santo André, São Paulo, Brazil., Nascimento M; Department of Urology, Faculdade de Medicina Do ABC, Santo André, São Paulo, Brazil., Farias A; Department of Urology, Faculdade de Medicina Do ABC, Santo André, São Paulo, Brazil., Mendez LC; Division of Radiation Oncology, London Regional Cancer Program, Western University, London, ON, Canada., Tafuri A; Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy., Glina S; Department of Urology, Faculdade de Medicina Do ABC, Santo André, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2022 Jul; Vol. 24 (7), pp. 1425-1439. Date of Electronic Publication: 2022 Mar 04.
DOI: 10.1007/s12094-022-02790-2
Abstrakt: Background: To compare toxicities in relation to standard radiation treatments [conventional fractionation RT (CRT) and moderate hypofractionated RT (MRT)] with ultrahypofractionated RT (URT) in the treatment of patients with localized PCa.
Methods: A searched was performed in Medline, Embase, Cochrane CENTRAL, and LILACS to January 2020 for studies comparing URT to CRT and/or MRT in relation to genitourinary (GU) and gastrointestinal (GI) toxicity in the treatment of patients with localized PCa. URT, MRT and CRT were defined as protocols delivering a daily dose of ≥5 Gy, 2.4-4.9 Gy, and <2.4 Gy per fractions regardless total dose, respectively.
Results: Eight studies with 2929 patients with localized PCa were included in the analysis. These eight studies did not find any difference between URT and MRT/CRT groups in relation to acute GU toxicity (21.0% × 23.8%, RD -0.04; 95% CI -0.13, 0.06; p = 0.46; I 2  = 89%) and acute GI toxicity (4.9% × 6.9%, RD -0.03; 95% CI -0.07, 0.01; p = 0.21; I 2  = 79%). Six studies did not find any difference between URT and MRT/CRT groups in relation to late GU toxicity (3.9% × 4.7%, RD -0.01; 95% CI -0.03, 0.00; p = 0.16; I 2  = 19%) and late GI toxicity (2.1% × 3.5%, RD -0.01; 95% CI -0.03, 0.00; p = 0.05; I 2  = 22%).
Conclusion: The present study suggests that acute GU/GI and late GU/GI toxicity are similar between URT and standard protocols. More studies with longer follow-ups directed to oncology outcomes are warranted before any recommendation on this topic.
(© 2022. The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO).)
Databáze: MEDLINE
Externí odkaz: