Sex Differences in Psychosis: Focus on Animal Models.

Autor:	Gogos A; Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia. andrea.gogos@florey.edu.au.; Department of Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia. andrea.gogos@florey.edu.au., van den Buuse M; School of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia.; Department of Pharmacology, University of Melbourne, Parkville, VIC, Australia.; College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, QLD, Australia.
Jazyk:	angličtina
Zdroj:	Current topics in behavioral neurosciences [Curr Top Behav Neurosci] 2023; Vol. 62, pp. 133-163.
DOI:	10.1007/7854_2022_305
Abstrakt:	Most psychiatric illnesses, such as schizophrenia, show profound sex differences in incidence, clinical presentation, course, and outcome. Fortunately, more recently the literature on sex differences and (to a lesser extent) effects of sex steroid hormones is expanding, and in this review we have focused on such studies in psychosis, both from a clinical/epidemiological and preclinical/animal model perspective. We begin by briefly describing the clinical evidence for sex differences in schizophrenia epidemiology, symptomatology, and pathophysiology. We then detail sex differences and sex hormone effects in behavioral animal models of psychosis, specifically psychotropic drug-induced locomotor hyperactivity and disruption of prepulse inhibition. We expand on the preclinical data to include developmental and genetic models of psychosis, such as the maternal immune activation model and neuregulin transgenic animals, respectively. Finally, we suggest several recommendations for future studies, in order to facilitate a better understanding of sex differences in the development of psychosis. (© 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.)
Databáze:	MEDLINE
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