SRXN1 blood levels negatively correlate with hippocampal atrophy and cognitive decline.

Autor:	Cucos CA; Victor Babes National Institute of Pathology, Bucharest, 050096, Romania., Cracana I; Medinst Diagnostic Romano-German SRL, Bucharest, Romania., Dobre M; Victor Babes National Institute of Pathology, Bucharest, 050096, Romania., Popescu BO; Victor Babes National Institute of Pathology, Bucharest, 050096, Romania.; 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania.; Clinical Hospital Colentina, Bucharest, Romania., Tudose C; 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania.; Prof. Dr. Al. Obregia' Psychiatry Clinical Hospital & the Memory Center of the Romanian Alzheimer Society, Section II, Bucharest, Romania., Spiru L; 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania.; 'Ana Aslan' International Foundation, Bucharest, Romania., Manda G; Victor Babes National Institute of Pathology, Bucharest, 050096, Romania., Niculescu G; Faculty of Medical Engineering, University Politehnica of Bucharest, Bucharest, Romania., Milanesi E; Victor Babes National Institute of Pathology, Bucharest, 050096, Romania.
Jazyk:	angličtina
Zdroj:	F1000Research [F1000Res] 2022 Jan 28; Vol. 11, pp. 114. Date of Electronic Publication: 2022 Jan 28 (Print Publication: 2022).
DOI:	10.12688/f1000research.76191.1
Abstrakt:	Introduction : Cognitive decline, correlating with hippocampal atrophy, characterizes several neurodegenerative disorders having a background of low-level chronic inflammation and oxidative stress. Methods : In this cross-sectional study, we examined how cognitive decline and hippocampal subfields volume are associated with the expression of redox and inflammatory genes in peripheral blood. We analyzed 34 individuals with different cognitive scores according to Mini-Mental State Examination, corrected by age and education (adjMMSE). We identified a group presenting cognitive decline (CD) with adjMMSE<27 (n=14) and a normal cognition (NC) group with adjMMSE≥27 (n=20). A multiparametric approach, comprising structural magnetic resonance imaging measurement of different hippocampal segments and blood mRNA expression of redox and inflammatory genes was applied. Results : Our findings indicate that hippocampal segment volumes correlate positively with adjMMSE and negatively with the blood transcript levels of 19 genes, mostly redox genes correlating especially with the left subiculum and presubiculum. A strong negative correlation between hippocampal subfields atrophy and SRXN1 redox gene is emphasized. Conclusions: Concluding, these results suggest that SRXN1 might be a valuable candidate blood biomarker for non-invasively monitoring the evolution of hippocampal atrophy in CD patients. Competing Interests: Competing interests: Author Ioana Cracana is employed by Medinst Diagnostic Romano-German SRL, Bucharest, Romania. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright: © 2022 Cucos CA et al.)
Databáze:	MEDLINE
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