Prophylactic and therapeutic insights into trained immunity: A renewed concept of innate immune memory.

Autor:	Bindu S; Immunology Section, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India., Dandapat S; Immunology Section, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India., Manikandan R; Immunology Section, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India., Dinesh M; Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India., Subbaiyan A; Division of Bacteriology and Mycology, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India., Mani P; Division of Animal Biochemistry, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India., Dhawan M; Department of Microbiology, Punjab Agricultural University, Ludhiana, India.; Indian Council of Agricultural Research, The Trafford Group of Colleges, Manchester, UK., Tiwari R; Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU), Mathura, India., Bilal M; School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huaian, China., Emran TB; Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, Bangladesh., Mitra S; Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangldesh., Rabaan AA; Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.; Department of Public Health and Nutrition, The University of Haripur, Haripur, Pakistan., Mutair AA; Research Center, Almoosa Specialist Hospital, Al-Ahsa, Saudi Arabia.; College of Nursing, Princess Norah Bint Abdulrahman University, Riyadh, Saudi Arabia.; School of Nursing, Wollongong University, Wollongong, Australia., Alawi ZA; Division of Allergy and Immunology, College of Medicine, King Faisal University, Saudi Arabia., Alhumaid S; Administration of Pharmaceutical Care, Al-Ahsa Health Cluster, Ministry of Health, Al-Ahsa, Saudi Arabia., Dhama K; Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India.
Jazyk:	angličtina
Zdroj:	Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2022 Dec 31; Vol. 18 (1), pp. 2040238. Date of Electronic Publication: 2022 Mar 03.
DOI:	10.1080/21645515.2022.2040238
Abstrakt:	Trained immunity is a renewed concept of innate immune memory that facilitates the innate immune system to have the capacity to remember and train cells via metabolic and transcriptional events to enable them to provide nonspecific defense against the subsequent encounters with a range of pathogens and acquire a quicker and more robust immune response, but different from the adaptive immune memory. Reversing the epigenetic changes or targeting the immunological pathways may be considered potential therapeutic approaches to counteract the hyper-responsive or hypo-responsive state of trained immunity. The efficient regulation of immune homeostasis and promotion or inhibition of immune responses is required for a balanced response. Trained immunity-based vaccines can serve as potent immune stimuli and help in the clearance of pathogens in the body through multiple or heterologous effects and confer protection against nonspecific and specific pathogens. This review highlights various features of trained immunity and its applications in developing novel therapeutics and vaccines, along with certain detrimental effects, challenges as well as future perspectives.
Databáze:	MEDLINE
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