Leveraging Potential of Nanotherapeutics in Management of Diabetic Foot Ulcer.

Autor:	Pandey S; Faculty of Pharmacy, Integral University, Dasauli-Kursi Road, Lucknow, India., Shaif M; Faculty of Pharmacy, Integral University, Dasauli-Kursi Road, Lucknow, India., Ansari TM; Faculty of Pharmacy, Integral University, Dasauli-Kursi Road, Lucknow, India., Shamim A; Faculty of Pharmacy, Integral University, Dasauli-Kursi Road, Lucknow, India., Kushwaha P; Faculty of Pharmacy, Integral University, Dasauli-Kursi Road, Lucknow, India.
Jazyk:	angličtina
Zdroj:	Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association [Exp Clin Endocrinol Diabetes] 2022 Oct; Vol. 130 (10), pp. 678-686. Date of Electronic Publication: 2022 Mar 03.
DOI:	10.1055/a-1749-4909
Abstrakt:	Diabetic foot ulcers (DFUs) are the most common complications associated with diabetes mellitus. DFUs are displayed as open sores or wounds located on the bottom of the foot as a secondary complication of diabetes mellitus (DM). DFUs are associated with significant morbidity and mortality and can subsequently lead to hospitalization and lower limb amputation if not recognized and treated on time. An immense challenge to conventional treatments is caused by the chronic nature of diabetic foot syndrome and it has led to the emergence of nanotechnology-based therapeutics. The greatest advantages of these nanotherapeutics are their unique biological, chemical, and physical properties. The present review highlights the augmentation of bacterial infections relating to delayed healing of DFUs and the potential of nanotherapeutics such as polymeric nanoparticles, metallic nanoparticles, siRNA-based nanoparticles, lipid nanoparticles, and nanofibers in accelerating wound healing in diabetic foot ulcers. Competing Interests: The authors declare that they have no conflict of interest (Thieme. All rights reserved.)
Databáze:	MEDLINE
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