Cytotoxic compounds from the leaf of Bersama abyssinica subspecies abyssinica.

Autor: Nyamboki DK; Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, TU Dortmund, Otto-Hahn-Straße 6, 44227, Dortmund, Germany; Department of Chemistry, Faculty of Sciences, Egerton University, P.O. Box 536, 20115, Egerton, Kenya., Bedane KG; Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, TU Dortmund, Otto-Hahn-Straße 6, 44227, Dortmund, Germany; Department of Chemistry, Addis Ababa University, P.O. Box 33658, Addis Ababa, Ethiopia., Hassan K; Department of Microbial Drugs, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 38124, Braunschweig, Germany., Spiteller M; Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, TU Dortmund, Otto-Hahn-Straße 6, 44227, Dortmund, Germany., Matasyoh JC; Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, TU Dortmund, Otto-Hahn-Straße 6, 44227, Dortmund, Germany; Department of Chemistry, Faculty of Sciences, Egerton University, P.O. Box 536, 20115, Egerton, Kenya. Electronic address: jmatasyoh@egerton.ac.ke.
Jazyk: angličtina
Zdroj: Phytochemistry [Phytochemistry] 2022 Jun; Vol. 198, pp. 113153. Date of Electronic Publication: 2022 Mar 01.
DOI: 10.1016/j.phytochem.2022.113153
Abstrakt: From the leaves of Kenyan medicinal plant Bersama abyssinica Subspecies abyssinica, four previously undescribed compounds namely, three bufadienolides, 10β-formylpaulliniogenin B, 10β-formylpaulliniogenin A and 1β-acetoxy-3β,5β-dihydroxy-15-methoxy-16,19-dioxobufa-14(15),20,22-trienolide, and a phenolic compound 2,6,4'-trihydroxybenzophenone-4-O-(6‴-cinnamoyl)-β-D-glucoside were isolated together with four known compounds. The structural elucidation of the compounds was based on 1D and 2D NMR spectroscopy and HRMS data analyses. The relative configurations were defined by NOESY correlations. Cytotoxic activities on L929 and KB3.1 cell lines of the isolated compounds were investigated using MTT assay. The 1β-acetoxy-3β,5β-dihydroxy-15-methoxy-16,19-dioxobufa-14(15),20,22-trienolide showed significant cytotoxic activity against KB3.1 cell lines with IC 50 of 3.9 ± 0.99 μM.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: