Lack of association between 11 gene polymorphisms on weight loss 1 year after Roux-en-y gastric bypass surgery in woman.

Autor: Novais PFS; Institute of Biosciences, Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, São Paulo, Brazil., Crisp AH; Human Performance Laboratory, Universidade Metodista de Piracicaba, Piracicaba, São Paulo, Brazil., Leandro-Merhi VA; Postgraduate Program in Health Sciences, PUC-Campinas, Campinas, São Paulo, Brazil., Verlengia R; Faculty of Health Sciences, Universidade Metodista de Piracicaba, Piracicaba, São Paulo, Brazil., Rasera I; Clínica Bariátrica de Piracicaba, Piracicaba, São Paulo, Brazil., de Oliveira MRM; Institute of Biosciences, Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Journal of human nutrition and dietetics : the official journal of the British Dietetic Association [J Hum Nutr Diet] 2022 Aug; Vol. 35 (4), pp. 731-738. Date of Electronic Publication: 2022 Mar 29.
DOI: 10.1111/jhn.13000
Abstrakt: Background: Although effective, the impact of bariatric surgery on weight loss is variable, and little is known about the influence of single-nucleotide polymorphisms (SNPs). The present study investigated the association of eleven SNPs related to obesity with weight loss 1 year after Roux-Y gastric bypass (RYGB) surgery in female patients.
Methods: This prospective study included 351 women with obesity. The genotypes for eleven SNPs (GHRL-rs26802; GHSR-rs572169; LEP-rs7799039; LEPR-rs1137101; 5HT2C-rs3813929; UCP2-rs659366; UCP3-rs1800849; SH2B1-rs7498665; TAS1R2-rs35874116; TAS1R2-rs9701796; FTO-rs9939609) were determined using a real-time polymerase chain reaction and TaqMan assays. Anthropometric measurements were performed before and 1 year after RYGB surgery. To evaluate the factors that influenced the proportion of weight loss 1 year after surgery, beta regression analysis was used. The models were estimated using the GLIMMIX procedure in SAS statistical software. p < 0.05 was considered statistically significant.
Results: The mean ± SD percentage of total body weight loss in 1 year was 64.4 ± 5.8% and the median was 65.0%. When assessing the proportion of weight loss in 1 year after surgery, using univariate analysis (beta regression), no SNPs influenced weight loss. Furthermore, in the multiple analysis, with stepwise process of variable selection, no variable was significant to compose the multiple model.
Conclusions: The 11 SNPs investigated did not influence weight loss 1 year after RYGB surgery in female patients. This result indicates that individual behaviours and other factors might better contribute to the magnitude of loss weight loss in a short period after bariatric surgery.
(© 2022 The British Dietetic Association Ltd.)
Databáze: MEDLINE
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