Purging of deleterious burden in the endangered Iberian lynx.

Autor: Kleinman-Ruiz D; Department of Integrative Ecology, Estación Biológica de Doñana, Consejo Superior de Investigaciones Cientificas, 41092 Seville, Spain.; Departamento de Genética, Fisiología y Microbiología, Facultad de Biología, Universidad Complutense, 28040 Madrid, Spain., Lucena-Perez M; Department of Integrative Ecology, Estación Biológica de Doñana, Consejo Superior de Investigaciones Cientificas, 41092 Seville, Spain., Villanueva B; Departamento de Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, 28040 Madrid, Spain., Fernández J; Departamento de Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, 28040 Madrid, Spain., Saveljev AP; Department of Animal Ecology, Russian Research Institute of Game Management and Fur Farming, 610000 Kirov, Russia., Ratkiewicz M; Faculty of Biology, University of Białystok, 15-245 Białystok, Poland., Schmidt K; Mammal Research Institute, Polish Academy of Sciences, 17-230 Białowieża, Poland., Galtier N; Institut des Sciences de l'Evolution, Université Montpellier, CNRS, Institut de Recherche pour le Développement, 34090 Montpellier, France., García-Dorado A; Departamento de Genética, Fisiología y Microbiología, Facultad de Biología, Universidad Complutense, 28040 Madrid, Spain., Godoy JA; Department of Integrative Ecology, Estación Biológica de Doñana, Consejo Superior de Investigaciones Cientificas, 41092 Seville, Spain.
Jazyk: angličtina
Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Mar 15; Vol. 119 (11), pp. e2110614119. Date of Electronic Publication: 2022 Mar 01.
DOI: 10.1073/pnas.2110614119
Abstrakt: SignificanceThe dynamics of deleterious variation under contrasting demographic scenarios remain poorly understood in spite of their relevance in evolutionary and conservation terms. Here we apply a genomic approach to study differences in the burden of deleterious alleles between the endangered Iberian lynx ( Lynx pardinus ) and the widespread Eurasian lynx ( Lynx lynx ). Our analysis unveils a significantly lower deleterious burden in the former species that should be ascribed to genetic purging, that is, to the increased opportunities of selection against recessive homozygotes due to the inbreeding caused by its smaller population size, as illustrated by our analytical predictions. This research provides theoretical and empirical evidence on the evolutionary relevance of genetic purging under certain demographic conditions.
Databáze: MEDLINE
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