[Effects of diet on the gut microbiome in patients with depression].

Autor:	Zorkina YA; Serbsky National Research Institute of Psychiatry and Narcology, Moscow, Russia.; Mental Health Clinic No. 1 named after N.A. Alexeev, Moscow, Russia., Syunyakov TS; Mental Health Clinic No. 1 named after N.A. Alexeev, Moscow, Russia., Abramova OV; Serbsky National Research Institute of Psychiatry and Narcology, Moscow, Russia.; Mental Health Clinic No. 1 named after N.A. Alexeev, Moscow, Russia., Yunes RA; Vavilov Institute of General Genetics RAS, Moscow, Russia., Averina OV; Vavilov Institute of General Genetics RAS, Moscow, Russia., Kovtun AS; Vavilov Institute of General Genetics RAS, Moscow, Russia.; Skoltech Center of Life Sciences, Moscow, Russia., Angelova IY; Moscow Institute of Physics and Technology (National Research University), Moscow, Russia., Khobta EB; Mental Health Clinic No. 1 named after N.A. Alexeev, Moscow, Russia., Susloparova DA; Mental Health Clinic No. 1 named after N.A. Alexeev, Moscow, Russia., Pavlichenko AV; Mental Health Clinic No. 1 named after N.A. Alexeev, Moscow, Russia., Karpenko OA; Mental Health Clinic No. 1 named after N.A. Alexeev, Moscow, Russia., Andreyuk DS; Mental Health Clinic No. 1 named after N.A. Alexeev, Moscow, Russia., Tovmasyan AS; Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow, Russia., Danilenko VN; Vavilov Institute of General Genetics RAS, Moscow, Russia., Gurina OI; Serbsky National Research Institute of Psychiatry and Narcology, Moscow, Russia., Kostyuk GP; Mental Health Clinic No. 1 named after N.A. Alexeev, Moscow, Russia., Morozova AY; Serbsky National Research Institute of Psychiatry and Narcology, Moscow, Russia.; Mental Health Clinic No. 1 named after N.A. Alexeev, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2022; Vol. 122 (1. Vyp. 2), pp. 59-64.
DOI:	10.17116/jnevro202212201259
Abstrakt:	Objective: To investigate the effects of diet on the gut microbiota and to assess the relationship of these factors with depression. Material and Methods: Microorganisms that predominate in depressed patients were identified and associations of the identified organisms with the patients' diet were performed. Fourteen depressed patients and 14 healthy volunteers with the same socio-demographic parameters were included in the study. The Hamilton Depression Scale, Generalized Anxiety Disorder Questionnaire, and the Center for Epidemiologic Studies Questionnaire were used. Results: Erysipelatoclostridium and Clostridium innocuum species were 11.3 and 14.4 times higher in depressed patients compared with healthy controls. Fusicatenibacter saccharivorans, Faecalibacterium prausnitzii and Roseburia faecis species , as well as members of the genus Roseburia were statistically significantly more abundant in the healthy volunteers group (6.5, 2.14, 8.75 and 5.2 times more frequently compared to patients). The presence of these microorganisms was correlated with dietary components. Conclusion: Our study revealed groups of microorganisms that differ in healthy volunteers and depressed patients. The association of these microorganisms with the diet was shown, which partially confirmed the influence of a «healthy diet» on the development of depressive disorders.
Databáze:	MEDLINE
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