Coupling of Heteroaryl Halides with Chlorodifluoroacetamides and Chlorodifluoroacetate by Nickel Catalysis.

Autor: Zhang D; Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences Chinese Academy of Sciences, 345 Lingling Lu, Shanghai, 200032, P. R. China., Gao X; Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences Chinese Academy of Sciences, 345 Lingling Lu, Shanghai, 200032, P. R. China., Min QQ; Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences Chinese Academy of Sciences, 345 Lingling Lu, Shanghai, 200032, P. R. China., Gu Y; Syngenta Jealott's Hill International Research Centre, Bracknell, RG42 6EY, UK., Berthon G; Syngenta Japan K.K., 21F, Office Tower X, 1-8-10. Harumi, Chuo, Tokyo, 104-6021, Japan., Zhang X; Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences Chinese Academy of Sciences, 345 Lingling Lu, Shanghai, 200032, P. R. China.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2022 May 06; Vol. 28 (26), pp. e202200642. Date of Electronic Publication: 2022 Mar 28.
DOI: 10.1002/chem.202200642
Abstrakt: A nickel-catalyzed cross-coupling of heteroaryl halides with chlorodifluoroacetamides and chlorodifluoroacetate has been developed. The combination of NiCl 2  ⋅ DME with 4,4'-diNon-bpy, co-ligand PPh 3 , and additive LiCl renders the catalytic system efficient for the synthesis of medicinal interest heteroaryldifluoroacetamides. The application of the method leads to short and highly efficient synthesis of biologically active molecules, providing a facile route for applications in medicinal chemistry and agrochemistry.
(© 2022 Wiley-VCH GmbH.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje