An Unusual Case of Multiple Myeloma with Light-Chain Cast Nephropathy Secondary to a Very Large Plasmacytoma without Bone Marrow Involvement.

Autor: Komisarof J; Department of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA., Lipof J; Department of Hematology and Oncology, Wilmot Cancer Institute, 601 Elmwood Avenue, Rochester, NY 14642, USA., DiTursi J; Department of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA., Chowdhry A; Department of Radiation Oncology, Wilmot Cancer Institute, 601 Elmwood Avenue, Rochester, NY 14642, USA., Grace Choung HY; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA., Burack WR; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA., Constine L; Department of Radiation Oncology, Wilmot Cancer Institute, 601 Elmwood Avenue, Rochester, NY 14642, USA., Passero F; Department of Hematology and Oncology, Wilmot Cancer Institute, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Jazyk: angličtina
Zdroj: Case reports in hematology [Case Rep Hematol] 2022 Feb 21; Vol. 2022, pp. 7531142. Date of Electronic Publication: 2022 Feb 21 (Print Publication: 2022).
DOI: 10.1155/2022/7531142
Abstrakt: Here, we report a case of a patient who presented to Strong Memorial Hospital with new-onset renal failure and anemia and was found to have multiple myeloma with lambda light-chain cast nephropathy secondary to a very large (14 cm × 14 cm × 12 cm) plasmacytoma without bone marrow involvement. This case is notable as solitary plasmacytomas are almost never seen with concomitant myeloma-defining CRAB criteria or significantly elevated serum free light-chain ratios. Although solitary plasmacytomas are typically definitively treated with radiation, this case highlights that systemic treatment may be helpful in certain clinical scenarios.
Competing Interests: The authors declare that they have no conflicts of interest. All authors are employed by the University of Rochester Medical Center.
(Copyright © 2022 Justin Komisarof et al.)
Databáze: MEDLINE
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