Distinct hepatic immunological patterns are associated with the progression or inhibition of hepatocellular carcinoma.

Autor:	Mirshahi F; Department of Internal Medicine, VCU School of Medicine, Richmond, VA 23298, USA., Aqbi HF; Department of Internal Medicine, VCU School of Medicine, Richmond, VA 23298, USA; VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA; College of Science, Mustansiriyah University, Baghdad, Iraq., Isbell M; Department of Microbiology & Immunology, VCU School of Medicine, Richmond, VA 23298, USA., Manjili SH; Department of Internal Medicine, VCU School of Medicine, Richmond, VA 23298, USA., Guo C; Department of Human & Molecular Genetics, VCU School of Medicine, Richmond, VA 23298, USA., Saneshaw M; VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA., Bandyopadhyay D; VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA; Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298, USA., Dozmorov M; VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA; Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298, USA., Khosla A; PathAI, Inc., Boston, MA 02215, USA., Wack K; PathAI, Inc., Boston, MA 02215, USA., Carrasco-Zevallos OM; PathAI, Inc., Boston, MA 02215, USA., Idowu MO; VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA; Department of Pathology, VCU School of Medicine, Richmond, VA 23298, USA., Wang XY; VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA; Department of Human & Molecular Genetics, VCU School of Medicine, Richmond, VA 23298, USA; Hunter Holmes McGuire VA Medical Center, Richmond, VA 23298, USA., Sanyal AJ; Department of Internal Medicine, VCU School of Medicine, Richmond, VA 23298, USA; VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA. Electronic address: arun.sanyal@vcuhealth.org., Manjili MH; Department of Microbiology & Immunology, VCU School of Medicine, Richmond, VA 23298, USA; VCU Massey Cancer Center, 401 College Street, Richmond, VA 23298, USA; Department of Pathology, VCU School of Medicine, Richmond, VA 23298, USA. Electronic address: masoud.manjili@vcuhealth.org.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2022 Mar 01; Vol. 38 (9), pp. 110454.
DOI:	10.1016/j.celrep.2022.110454
Abstrakt:	To discover distinct immune responses promoting or inhibiting hepatocellular carcinoma (HCC), we perform a three-dimensional analysis of the immune cells, correlating immune cell types, interactions, and changes over time in an animal model displaying gender disparity in nonalcoholic fatty liver disease (NAFLD)-associated HCC. In response to a Western diet (WD), animals mount acute and chronic patterns of inflammatory cytokines, respectively. Tumor progression in males and females is associated with a predominant CD8 + > CD4 + , Th1 > Th17 > Th2, NKT > NK, M1 > M2 pattern in the liver. A complete rescue of females from HCC is associated with an equilibrium Th1 = Th17 = Th2, NKT = NK, M1 = M2 pattern, while a partial rescue of males from HCC is associated with an equilibrium CD8 +  = CD4 + , NKT = NK and a semi-equilibrium Th1 = Th17 > Th2 but a sustained M1 > M2 pattern in the liver. Our data suggest that immunological pattern-recognition can explain immunobiology of HCC and guide immune modulatory interventions for the treatment of HCC in a gender-specific manner. Competing Interests: Declaration of interests A.J.S. is the President of Sanyal Biotechnology. A.J.S. and F.M. are shareholders in Sanyal Biotechnology and hold a patent on DIAMOND mouse model, PCT/US2016/056506. (Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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