Microvascular remodeling following skin injury.

Autor: Wikslund LK; Ostfold Hospital Trust, Gralum, Norway.; Circulation laboratory, Department of Cardio-thoracic Surgery, Oslo University Hospital, Ullevaal, Norway.; Medical Faculty, University of Oslo, Oslo, Norway., Kaljusto ML; Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway., Amundsen VS; Circulation laboratory, Department of Cardio-thoracic Surgery, Oslo University Hospital, Ullevaal, Norway., Kvernebo K; Circulation laboratory, Department of Cardio-thoracic Surgery, Oslo University Hospital, Ullevaal, Norway.; Medical Faculty, University of Oslo, Oslo, Norway.; Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway.
Jazyk: angličtina
Zdroj: Microcirculation (New York, N.Y. : 1994) [Microcirculation] 2022 Oct; Vol. 29 (6-7), pp. e12755. Date of Electronic Publication: 2022 Mar 17.
DOI: 10.1111/micc.12755
Abstrakt: Objective: The aim of this study was to describe possible remodeling (i.e., dilatation and elongation) of papillary capillaries induced by increased oxygen demand for the repair process following a skin wound.
Methods: Computer-assisted video microscopy was used to examine 10 healthy volunteers before (baseline) and after (≈1 h and ≈24 h) an incision (5 mm long and 1 mm deep) on the forearm, 0-1 mm and 30 mm (control site) from the incision. We defined categories from 0 (low) to 3 (high) to grade dilatation and elongation of the nutritive papillary capillaries, as well as the visibility of the superficial vascular plexus. Approximately 10 000 capillaries from 200 films were scored.
Results: The nutritive papillary capillaries were dilated and elongated (p < 0.01) after ≈24 h; that is, elongation (score 1.9 ± 0.9) vs baseline (score 0.9 ± 0.6), p < 0.01 and dilatation (score 2.2 ± 0.7) vs baseline (score 0.3 ± 0.3), p < 0.01. Superficial plexus visibility increased (p < 0.01) after ≈1 h (score 2.0 ± 0.7) and ≈24 h (score 2.7 ± 0.3) vs baseline (score 0.8 ± 0.4).
Conclusion: The superficial vascular skin plexus showed enhanced visibility already ≈1 h after the skin trauma. Morphological remodeling in the nutritive papillary capillaries-dilatation and elongation after ≈24 h-facilitate increased O 2  supply.
(© 2022 The Authors. Microcirculation published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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