SARS-COV-2 genomic monitoring in the state of São Paulo unveils two emerging AY.43 sublineages.

Autor:	Lima ARJ; Center of Scientific Development, Butantan Institute, São Paulo, Brazil., Ribeiro G; Center of Scientific Development, Butantan Institute, São Paulo, Brazil., Viala VL; Center of Scientific Development, Butantan Institute, São Paulo, Brazil., de Lima LPO; Center of Scientific Development, Butantan Institute, São Paulo, Brazil., Martins AJ; Center of Scientific Development, Butantan Institute, São Paulo, Brazil., Barros CRDS; Center of Scientific Development, Butantan Institute, São Paulo, Brazil., Marqueze EC; Center of Scientific Development, Butantan Institute, São Paulo, Brazil., Bernardino JST; Center of Scientific Development, Butantan Institute, São Paulo, Brazil., Moretti DB; Center of Scientific Development, Butantan Institute, São Paulo, Brazil., Rodrigues ES; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Santos EV; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Brassaloti RA; Centro de Genômica Funcional da ESALQ, University of São Paulo, Piracicaba, São Paulo, Brazil., Cassano RLRC; Centro de Genômica Funcional da ESALQ, University of São Paulo, Piracicaba, São Paulo, Brazil., Mariani PDSC; NGS Soluções Genômicas, Piracicaba, São Paulo, Brazil., Clemente LG; Centro de Genômica Funcional da ESALQ, University of São Paulo, Piracicaba, São Paulo, Brazil., Assato PA; Department of Bioprocesses and Biotechnology, School of Agricultural Sciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil., Costa FADSD; Department of Bioprocesses and Biotechnology, School of Agricultural Sciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil., Poleti MD; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, São Paulo, Brazil., Lesbon JCC; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, São Paulo, Brazil., Mattos EC; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, São Paulo, Brazil., Banho CA; Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil., Sacchetto L; Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil., Moraes MM; Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil., Palmieri M; Coordenação de Vigilância em Saúde-Secretaria Municipal da Saúde, São Paulo, Brazil., Martininghi M; Secretaria Municipal da Saúde, São Paulo, Brazil., Caldeira LAV; Secretaria Municipal da Saúde, São Paulo, Brazil., Silva FEVD; Secretaria Municipal da Saúde, São Paulo, Brazil., Grotto RMT; Department of Bioprocesses and Biotechnology, School of Agricultural Sciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.; Molecular Biology Laboratory, Applied Biotechnology Laboratory, Clinical Hospital of the Botucatu Medical School, Botucatu, São Paulo, Brazil., Souza-Neto JA; Department of Bioprocesses and Biotechnology, School of Agricultural Sciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil., Giovanetti M; Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Laboratório de Flavivírus, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil., Junior Alcantara LC; Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Laboratório de Flavivírus, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil., Nogueira ML; Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil., Fukumasu H; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga, São Paulo, Brazil., Coutinho LL; Centro de Genômica Funcional da ESALQ, University of São Paulo, Piracicaba, São Paulo, Brazil., Kashima S; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Neto RM; Center of Scientific Development, Butantan Institute, São Paulo, Brazil., Covas DT; Center of Scientific Development, Butantan Institute, São Paulo, Brazil.; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Slavov SN; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Sampaio SC; Center of Scientific Development, Butantan Institute, São Paulo, Brazil., Elias MC; Center of Scientific Development, Butantan Institute, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of medical virology [J Med Virol] 2022 Jul; Vol. 94 (7), pp. 3394-3398. Date of Electronic Publication: 2022 Mar 12.
DOI:	10.1002/jmv.27674
Abstrakt:	Delta VOC is highly diverse with more than 120 sublineages already described as of November 30, 2021. In this study, through active monitoring of circulating severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants in the state of São Paulo, southeast Brazil, we identified two emerging sublineages from the ancestral AY.43 strain which were classified as AY.43.1 and AY.43.2. These sublineages were defined by the following characteristic nonsynonymous mutations ORF1ab:A4133V and ORF3a:T14I for the AY.43.1 and ORF1ab:G1155C for the AY.43.2 and our analysis reveals that they might have a likely-Brazilian origin. Much is still unknown regarding their dissemination in the state of São Paulo and Brazil as well as their potential impact on the ongoing vaccination process. However, the results obtained in this study reinforce the importance of genomic surveillance activity for timely identification of emerging SARS-CoV-2 variants which can impact the ongoing SARS-CoV-2 vaccination and public health policies. (© 2022 Wiley Periodicals LLC.)
Databáze:	MEDLINE
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