Functional network connectivity imprint in febrile seizures.

Autor: Acharya UV; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, 560029, Karnataka, India., Kulanthaivelu K; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, 560029, Karnataka, India., Panda R; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, 560029, Karnataka, India.; Coma Science Group and GIGA - Consciousness, University of Liege, Liege, 4000, Belgium., Saini J; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, 560029, Karnataka, India., Gupta AK; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, 560029, Karnataka, India., Sankaran BP; Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, 560029, Karnataka, India., Raghavendra K; Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, 560029, Karnataka, India., Mundlamuri RC; Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, 560029, Karnataka, India., Sinha S; Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, 560029, Karnataka, India., Keshavamurthy ML; Department of Paediatric Medicine, Indira Gandhi Institute of Child Health, Bengaluru, 560029, Karnataka, India., Bharath RD; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, 560029, Karnataka, India. drrosedawnbharath@gmail.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Feb 28; Vol. 12 (1), pp. 3267. Date of Electronic Publication: 2022 Feb 28.
DOI: 10.1038/s41598-022-07173-9
Abstrakt: Complex febrile seizures (CFS), a subset of paediatric febrile seizures (FS), have been studied for their prognosis, epileptogenic potential and neurocognitive outcome. We evaluated their functional connectivity differences with simple febrile seizures (SFS) in children with recent-onset FS. Resting-state fMRI (rs-fMRI) datasets of 24 children with recently diagnosed FS (SFS-n = 11; CFS-n = 13) were analysed. Functional connectivity (FC) was estimated using time series correlation of seed region-to-whole-brain-voxels and network topology was assessed using graph theory measures. Regional connectivity differences were correlated with clinical characteristics (FDR corrected p < 0.05). CFS patients demonstrated increased FC of the bilateral middle temporal pole (MTP), and bilateral thalami when compared to SFS. Network topology study revealed increased clustering coefficient and decreased participation coefficient in basal ganglia and thalamus suggesting an inefficient-unbalanced network topology in patients with CFS. The number of seizure recurrences negatively correlated with the integration of Left Thalamus (r = - 0.58) and FC of Left MTP to 'Right Supplementary Motor and left Precentral' gyrus (r = - 0.53). The FC of Right MTP to Left Amygdala, Putamen, Parahippocampal, and Orbital Frontal Cortex (r = 0.61) and FC of Left Thalamus to left Putamen, Pallidum, Caudate, Thalamus Hippocampus and Insula (r 0.55) showed a positive correlation to the duration of the longest seizure. The findings of the current study report altered connectivity in children with CFS proportional to the seizure recurrence and duration. Regardless of the causal/consequential nature, such observations demonstrate the imprint of these disease-defining variables of febrile seizures on the developing brain.
(© 2022. The Author(s).)
Databáze: MEDLINE
Nepřihlášeným uživatelům se plný text nezobrazuje