Cognitive Frailty is Associated With Elevated Proinflammatory Markers and a Higher Risk of Mortality.

Autor:	Diniz BS; UConn Center on Aging (BSD, GAK), University of Connecticut Health Center, Farmington, CT; Department of Psychiatry, School of Medicine (BSD), University of Connecticut Health Center, Farmington, CT. Electronic address: diniz@uchc.edu., Lima-Costa MF; Center for Studies in Public Health and Aging (NESPE) (MFLC, SVP, JOAF, ECC), Rene Rachou Research Center, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil., Peixoto SV; Center for Studies in Public Health and Aging (NESPE) (MFLC, SVP, JOAF, ECC), Rene Rachou Research Center, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil; Nursing School (SVP), Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Firmo JOA; Center for Studies in Public Health and Aging (NESPE) (MFLC, SVP, JOAF, ECC), Rene Rachou Research Center, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil., Torres KCL; Integrated Research Group on Biomarkers, Rene Rachou Research Center (KCLT, OAMF, ATC), Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil; Faculty of Medicine (KCLT), University José do Rosário Vellano, UNIFENAS, Belo Horizonte, Minas Gerais, Brazil., Martins-Filho OA; Integrated Research Group on Biomarkers, Rene Rachou Research Center (KCLT, OAMF, ATC), Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil., Teixeira-Carvalho A; Integrated Research Group on Biomarkers, Rene Rachou Research Center (KCLT, OAMF, ATC), Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil., Grady J; Department of Public Health Sciences, School of Medicine (JG), University of Connecticut Health Center, Farmington, CT., Kuchel GA; UConn Center on Aging (BSD, GAK), University of Connecticut Health Center, Farmington, CT., Castro-Costa E; Center for Studies in Public Health and Aging (NESPE) (MFLC, SVP, JOAF, ECC), Rene Rachou Research Center, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil.
Jazyk:	angličtina
Zdroj:	The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry [Am J Geriatr Psychiatry] 2022 Jul; Vol. 30 (7), pp. 825-833. Date of Electronic Publication: 2022 Feb 03.
DOI:	10.1016/j.jagp.2022.01.012
Abstrakt:	Background: Cognitive impairment and physical frailty are common among older adults and associated with a higher likelihood of adverse health outcomes. These two conditions frequently coexist in the same individual as cognitive frailty, yet few studies have examined the impact of such comorbidity on clinical outcomes or underlying biological mechanisms. Methods: A total of 1,340 older adults (age ≥60 years old) from the Bambui Cohort Study of Ageing, with a total follow-up of 10 years, were included in this study. Frailty was defined by the accumulation of deficit framework and cognitive impairment based on scores on the MMSE less than 22. In addition, serum IL-6 levels were measured by cytometric bead array assay. Results: Individuals classified with cognitive frailty had significantly higher serum IL-6 levels compared to the robust, cognitively unimpaired group. Those with cognitive frailty (aOR = 1.97 [1.18-3.27] and prefrailty and cognitive impairment (aOR = 1.83 [1.24-2.69]) had the highest mortality risk over 10 years of follow-up. Higher IL-6 levels were also independently associated with a higher mortality rate (aOR = 1.37 [1.23-1.54]). Conclusion: Our study shows that cognitive Frailty indicates a vulnerability state and of increasing mortality risk. Our findings also suggested that proinflammatory abnormalities can be viewed as a central phenomenon underlying common age-related problems (e.g., cognitive impairment and Frailty) and outcomes (e.g., mortality). (Copyright © 2022 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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