Immune response to influenza and pneumococcal vaccines in adults with inflammatory bowel disease: A systematic review and meta-analysis of 1429 patients.

Autor: Müller KE; Institute for Translational Medicine, Medical School, University of Pécs, Szigeti street 12, 7624 Pécs, Hungary; Heim Pál National Pediatric Institute, Üllői street 89, 1086 Budapest, Hungary., Dohos D; Institute for Translational Medicine, Medical School, University of Pécs, Szigeti street 12, 7624 Pécs, Hungary; Szentágothai Research Centre, University of Pécs, Ifjúság útja 20, 7624 Pécs, Hungary., Sipos Z; Institute for Translational Medicine, Medical School, University of Pécs, Szigeti street 12, 7624 Pécs, Hungary., Kiss S; Institute for Translational Medicine, Medical School, University of Pécs, Szigeti street 12, 7624 Pécs, Hungary; Doctoral School of Clinical Medicine, University of Szeged, Dugonics tér 13, 6720 Szeged, Hungary., Dembrovszky F; Institute for Translational Medicine, Medical School, University of Pécs, Szigeti street 12, 7624 Pécs, Hungary; Szentágothai Research Centre, University of Pécs, Ifjúság útja 20, 7624 Pécs, Hungary., Kovács N; Institute for Translational Medicine, Medical School, University of Pécs, Szigeti street 12, 7624 Pécs, Hungary; Doctoral School of Clinical Medicine, University of Szeged, Dugonics tér 13, 6720 Szeged, Hungary., Solymár M; Institute for Translational Medicine, Medical School, University of Pécs, Szigeti street 12, 7624 Pécs, Hungary., Erőss B; Institute for Translational Medicine, Medical School, University of Pécs, Szigeti street 12, 7624 Pécs, Hungary; Szentágothai Research Centre, University of Pécs, Ifjúság útja 20, 7624 Pécs, Hungary., Hegyi P; Institute for Translational Medicine, Medical School, University of Pécs, Szigeti street 12, 7624 Pécs, Hungary; Centre for Translational Medicine, Semmelweis University, Budapest, Hungary; Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Sarlós P; Institute for Translational Medicine, Medical School, University of Pécs, Szigeti street 12, 7624 Pécs, Hungary; Division of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Ifjúság street 13, 7624 Pécs, Hungary.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2022 Mar 18; Vol. 40 (13), pp. 2076-2086. Date of Electronic Publication: 2022 Feb 25.
DOI: 10.1016/j.vaccine.2022.02.027
Abstrakt: Background: Patients with inflammatory bowel disease (IBD) have a high risk for infection. Pneumonia related to influenza and pneumococcal infection is one of the most common infection-related complications in IBD.
Aims: To evaluate the immunogenicity of pneumococcal and influenza vaccination in patients with IBD receiving different treatments.
Methods: We searched four databases for studies evaluating seroprotection and seroconversion rates after influenza or pneumococcal vaccination in IBD on 20th October 2020. In the meta-analysis, odds ratios (OR) were calculated with 95% confidence intervals (CI).
Results: We included twelve studies (1429 patients with IBD) in this meta-analysis. The seroconversion rate after pneumococcal vaccination and the seroprotection rate after influenza vaccination were not significantly lower in patients receiving conventional immunosuppressive treatment compared to the non-immunosuppressed patients. Meanwhile, the seroconversion rate following pneumococcal vaccine was significantly lower in patients with anti-TNF mono- or combination therapy (OR = 0.28, CI: 0.15-0.53, and OR = 0.27, CI: 0.15-0.49, respectively). In the analysis of patients with IBD on conventional immunosuppressive monotherapy versus anti-TNF therapy, the seroprotection rate after influenza immunization did not differ between patients receiving either anti-TNF mono-or combination therapy (OR = 1.45, CI: 0.62-3.38 and OR = 0.91, CI: 0.37-2.22, respectively).
Conclusion: Our data suggest that the immunization against Pneumococcus and influenza is safe and immunogenic despite immunosuppression.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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