Comparative analysis of the dispersion quality of oxymetazoline nasal sprays.

Autor: Gobyzov OA; Laboratory of Transfer Processes in Multiphase Systems, S. S. Kutateladze Institute of Thermophysics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Ryabov MN; Laboratory of Transfer Processes in Multiphase Systems, S. S. Kutateladze Institute of Thermophysics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Yankova VG; Chair of Analytical, Physical and Colloid Chemistry, The Institute of Pharmacy, I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Gribanova SV; Chair of Analytical, Physical and Colloid Chemistry, The Institute of Pharmacy, I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Slonskaya TK; Chair of Analytical, Physical and Colloid Chemistry, The Institute of Pharmacy, I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Udyanskaya IL; Chair of Analytical, Physical and Colloid Chemistry, The Institute of Pharmacy, I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Zhukova AA; Chair of Analytical, Physical and Colloid Chemistry, The Institute of Pharmacy, I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Grigoryeva VY; Chair of Analytical, Physical and Colloid Chemistry, The Institute of Pharmacy, I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Jazyk: angličtina
Zdroj: Journal of advanced pharmaceutical technology & research [J Adv Pharm Technol Res] 2022 Jan-Mar; Vol. 13 (1), pp. 30-37. Date of Electronic Publication: 2022 Jan 21.
DOI: 10.4103/japtr.japtr_240_21
Abstrakt: Metered-dose nasal sprays (MDNS) are the most widely used for treating rhinitis. Medicinal preparations in the pharmaceutical market vary in their characteristics. To identify the most effective drug, it is necessary to compare the preparations regarding various parameters. The purpose of the research was to compare oxymetazoline MDNS of different brands regarding their dispersion qualities. To that end, nine oxymetazoline sprays available in the Russian market were chosen and analyzed considering their dynamic characteristics and the spraying dispersion composition. The research was conducted with the shadow photography method, the selection of which was justified by its simplicity, the possibilities for detecting the spray jet composition, the process of its formation in dynamics, and the possibility for measuring droplets of all forms. Momentary images of spray activation phases, as well as an averaged image of 100 shots of the spraying main phase, were obtained. According to a range of characteristics, such as spraying duration, a cone angle and cone structure, all the preparations were grouped into three categories. It was found out that the sprays from Group 2 had the best dynamic rates of dispersion, with Vicks Sinex having the best results. Regarding the distribution of particles of different size, the most optimal composition was found for the drugs from Group 2, particularly, Vicks Sinex and Afrin preparations. Hence, Vicks Sinex spraying regimen and microsprayer design were found the most effective for delivering the medicinal substance to the destination.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2022 Journal of Advanced Pharmaceutical Technology & Research.)
Databáze: MEDLINE
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