Age-dependency of EHRA improvement based on quality of life at diagnosis of atrial fibrillation.

Autor: Theunissen LJHJ; Máxima Medical Center Veldhoven The Netherlands., Cremers HP; Netherlands Heart Network Eindhoven The Netherlands., van Veghel D; Netherlands Heart Network Eindhoven The Netherlands.; Catharina Hospital Eindhoven Eindhoven The Netherlands., van der Voort PH; Catharina Hospital Eindhoven Eindhoven The Netherlands., Polak PE; St. Anna Hospital Geldrop The Netherlands., de Jong SFAMS; Elkerliek Hospital Helmond The Netherlands., Smits G; GP Organization PoZoB Helmond The Netherlands., Dijkmans J; GP Organization DOH Eindhoven The Netherlands., Kemps HMC; Máxima Medical Center Veldhoven The Netherlands.; Department of Industrial Design Eindhoven University of Technology (TUe) Eindhoven The Netherlands., Dekker LRC; Catharina Hospital Eindhoven Eindhoven The Netherlands.; Department of Electrical Engineering Eindhoven University of Technology (TUe) Eindhoven The Netherlands., van de Pol JAA; Netherlands Heart Network Eindhoven The Netherlands.; Department of Electrical Engineering Eindhoven University of Technology (TUe) Eindhoven The Netherlands.
Jazyk: angličtina
Zdroj: Journal of arrhythmia [J Arrhythm] 2022 Jan 10; Vol. 38 (1), pp. 50-57. Date of Electronic Publication: 2022 Jan 10 (Print Publication: 2022).
DOI: 10.1002/joa3.12671
Abstrakt: Background: In this study, the relationship between AF-related quality of life (AFEQT) at baseline in AF-patients and the improvement on perceived symptoms and general state of health (EHRA, European Heart Rhythm Association score) at 12 months was assessed across predefined age categories.
Methods: Between November 2014 and October 2019 patients diagnosed with AF de novo in four hospitals embedded within the Netherlands Heart Network were prospectively followed for 12 months. These AF-patients were categorized into quartiles based on their AFEQT score at diagnosis and EHRA score was measured at diagnosis and 12 months of follow-up. Stratified analyses were performed using age categories (<65 vs. ≥65 years; <75 vs. ≥75 years).
Results: In total, 203/483 (42.0%) AF-patients improved in EHRA score after 12 months of follow-up. AF-patients in the lowest AFEQT quartile were more likely to improve, compared to patients in the highest AFEQT quartile (OR [95%CI]:4.73 [2.63-8.50]). Furthermore, patients ≥65 years and patients <75 years at diagnosis with lower AFEQT scores at baseline were most likely to improve in EHRA score after 12 months, compared to similarly aged patients with higher AFEQT scores at baseline.
Conclusion: The present study indicates that AF-patients with a lower quality of life at diagnosis were most likely to improve their EHRA score after 12 months. This effect was most prominent in patients ≥65 years of age and patients <75 years of age, compared to patients >65 and ≥75 years, respectively. Future research should focus on further defining characteristics of these age groups to enable the implementation of age-tailored treatment.
Competing Interests: All authors declare no conflicts of interest. The sponsors of the Netherlands Heart Network were not in any way involved in the design, conduct, analysis, or writing of this manuscript.
(© 2022 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Heart Rhythm Society.)
Databáze: MEDLINE
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