Modulation of Emotion Perception via Amygdala Stimulation in Humans.

Autor:	Bujarski KA; Department of Neurology, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States., Song Y; Department of Neurology, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States., Xie T; Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, United States.; Department of Quantitative Biomedical Sciences, Dartmouth College, Lebanon, NH, United States., Leeds Z; Department of Neurology, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States., Kolankiewicz SI; Department of Neurology, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States., Wozniak GH; Department of Neurology, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States., Guillory S; Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, United States., Aronson JP; Department of Surgery, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States., Chang L; Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, United States., Jobst BC; Department of Neurology, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2022 Feb 09; Vol. 15, pp. 795318. Date of Electronic Publication: 2022 Feb 09 (Print Publication: 2021).
DOI:	10.3389/fnins.2021.795318
Abstrakt:	Background: Multiple lines of evidence show that the human amygdala is part of a neural network important for perception of emotion from environmental stimuli, including for processing of intrinsic attractiveness/"goodness" or averseness/"badness," i.e., affective valence. Objective/hypothesis: With this in mind, we investigated the effect of electrical brain stimulation of the human amygdala on perception of affective valence of images taken from the International Affective Picture Set (IAPS). Methods: Using intracranial electrodes in patients with epilepsy, we first obtained event-related potentials (ERPs) in eight patients as they viewed IAPS images of varying affective valence. Next, in a further cohort of 10 patients (five female and five male), we measured the effect of 50 Hz electrical stimulation of the left amygdala on perception of affective valence from IAPS images. Results: We recorded distinct ERPs from the left amygdala and found significant differences in the responses between positively and negatively valenced stimuli ( p = 0.002), and between neutral and negatively valenced stimuli ( p = 0.017) 300-500 ms after stimulus onset. Next, we found that amygdala stimulation did not significantly affect how patients perceived valence for neutral images ( p = 0.58), whereas stimulation induced patients to report both positively ( p = 0.05) and negatively (< 0.01) valenced images as more neutral. Conclusion: These results render further evidence that the left amygdala participates in a neural network for perception of emotion from environmental stimuli. These findings support the idea that electrical stimulation disrupts this network and leads to partial disruption of perception of emotion. Harnessing this effect may have clinical implications in treatment of certain neuropsychiatric disorders using deep brain stimulation (DBS) and neuromodulation. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Bujarski, Song, Xie, Leeds, Kolankiewicz, Wozniak, Guillory, Aronson, Chang and Jobst.)
Databáze:	MEDLINE
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