Prevalence of antibiotic resistance pattern in shigella isolates procured from pediatric patients at Faisalabad - Pakistan.

Autor: Khan SU; Institute of Microbiology, University of Agriculture, Faisalabad, Pakistan., Aslam R; Institute of Microbiology, University of Agriculture, Faisalabad, Pakistan., Ashraf M; Institute of Microbiology, University of Agriculture, Faisalabad, Pakistan., Ali S; Institute of Microbiology, University of Agriculture, Faisalabad, Pakistan., Saqib M; Department of Clinical Medicine and Surgery, University of Agriculture, Faisalabad, Pakistan., Khattak MA; Department of Mathematics and Statistics, University of Agriculture, Faisalabad, Pakistan., Khattak US; College of Veterinary Sciences, Faculty of Animal Husbandry & Veterinary Sciences (FAHVS) The University of Agriculture, Peshawar, Pakistan., Amanullah H; College of Veterinary Sciences, Faculty of Animal Husbandry & Veterinary Sciences (FAHVS) The University of Agriculture, Peshawar, Pakistan., Wuryastuty H; Department of Veterinary Internal Medicine, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia., Wasito R; Department of Pathology, Faculty of Veterinary Medicine, Universitas Gadjah Mada Jl. Yogyakarta, Indonesia., Haryanto A; Department of Biochemistry and Molecular Biologi, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia., Ullah F; Faculty of Veterinary and Animal Sciences, Department of Animal Breeding and Genetics, National Center for Livestock Breeding Genetics and Genomics LUAWMS, Uthal, Pakistan., Ma M; Department of Applied Microbiology, College of Resources, Sichuan Agricultural University, Sichuan, PR China., Ali S; Department of Applied Microbiology, College of Resources, Sichuan Agricultural University, Sichuan, PR China.
Jazyk: angličtina
Zdroj: Pakistan journal of pharmaceutical sciences [Pak J Pharm Sci] 2022 Jan; Vol. 35 (1), pp. 41-48.
Abstrakt: Shigella infection (shigellosis) is an intestinal disease caused by a shigella isolates belongs to a family Enterobacteriacea. Watery diarrhea, abdominal pain and tenesmus are the prominent symptoms of shigella infection. The present study was designed to determine period prevalence and antimicrobial susceptibility of Shigella species recovered from stool specimens obtained from diarrheal paediatric patients under 5 years of age. This cross-sectional study was carried out for a period of six months (Jan to June, 2016). All Shigella isolates were identified based on colony morphology, microscopic characteristics, and biochemical characteristics. After applying Kirby Baur disc diffusion method only 22 (18.96%) stool specimens were found positive for Shigella isolates among the 116 stool specimens. The isolates were also found susceptible to Levofloxacin (72.72%), Azithromycin (59.09%), and Cefotaxime (40.90%). However, the said isolates were resistant to Lincomycin (100%) and Penicillin-G (100%), followed by Amoxicillin (95.45%) and Oxacillin (95.45%). The chi-square test was used to check the close association among antimicrobial agents used and as highly significant (p-value < 2.2e-16). Based on antimicrobial susceptibility findings, Levofloxacin, Azithromycin and Cefotoxime were found effective for the control of shigellosis.
Databáze: MEDLINE