Implementation of HCV screening in the 1969-1989 birth-cohort undergoing COVID-19 vaccination.

Autor: D'Ambrosio R; Division of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Rizzardini G; ASST Fatebenefratelli-Sacco, First Division of Infectious Diseases, Milan, Italy., Puoti M; ASST Grande Ospedale Metropolitano Niguarda, Division of Infectious Diseases, Milan, Italy., Fagiuoli S; AAST Papa Giovanni XXIII, Gastroenterology, Hepatology and Transplantation, Bergamo, Italy., Anolli MP; Division of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Gabiati C; ASST Fatebenefratelli-Sacco, Division of Internal Medicine, Milan, Italy., D'Amico F; ASST Grande Ospedale Metropolitano Niguarda, Division of Infectious Diseases, Milan, Italy., Pasulo L; AAST Papa Giovanni XXIII, Gastroenterology, Hepatology and Transplantation, Bergamo, Italy., Restelli U; LIUC Cattaneo University, Castellanza (VA), Italy.; Faculty of Health Sciences, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa., Colombo M; Liver Center, Ospedale San Raffaele, Milan, Italy., Lampertico P; Division of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; CRC 'A. M. and A. Migliavacca' Center for Liver Diseases, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Jazyk: angličtina
Zdroj: Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2022 May; Vol. 42 (5), pp. 1012-1016. Date of Electronic Publication: 2022 Mar 12.
DOI: 10.1111/liv.15216
Abstrakt: Background and Aim: The World Health Organization (WHO) goal of hepatitis C virus (HCV) elimination by 2030 relies on the scaling-up of both identification and linkage to care of the infected population, worldwide. In Italy, the estimated burden of HCV carriers who are unaware of their infection amounts to 200 000 persons, a projection that reinforces the need for broadening population access to effective screening programmes.
Methods: A pivotal screening programme targeting subjects born between 1969 and 1989 has been conducted in Lombardy, Northern Italy, where point-of-care (POC) testing was offered for free concomitantly to COVID-19 vaccination.
Results: Amongst 7219 subjects born between 1969 and 1989 who underwent HCV screening through POC, 7 (0.10%) subjects tested anti-HCV positive: 5 (0.07%) had confirmed anti-HCV positivity (Table 1) and 4 of them (0.05%) were HCV-RNA positive by standard confirmation tests.
Conclusions: This pivotal study demonstrated the feasibility of a POC-based anti-HCV screening programme in young adults undergoing COVID-19 vaccination. The prevalence of HCV infection in subjects born in the 1969-1989 cohort in Italy seems to be lower than previously estimated. Whether the extension of this programme to subjects born before 1969 could lead to improved screening effectiveness should be a matter of debate.
(© 2022 John Wiley & Sons A/S . Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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