Simplified screening approach of anabolic steroid esters using a compact atmospheric solid analysis probe mass spectrometric system.

Autor: Arrizabalaga-Larrañaga A; Department of Chemical Engineering and Analytical Chemistry, University of Barcelona, Av. Diagonal 645, 08028, Barcelona, Spain. a.arrizabalaga@ub.edu., Zoontjes PW; Wageningen Food Safety Research (WFSR), Part of Wageningen University & Research, P.O. Box 230, 6700 AE, Wageningen, The Netherlands., Lasaroms JJP; Wageningen Food Safety Research (WFSR), Part of Wageningen University & Research, P.O. Box 230, 6700 AE, Wageningen, The Netherlands., Nielen MWF; Wageningen Food Safety Research (WFSR), Part of Wageningen University & Research, P.O. Box 230, 6700 AE, Wageningen, The Netherlands.; Laboratory of Organic Chemistry, Wageningen University, Stippeneng 4, 6708 WE, Wageningen, The Netherlands., Blokland MH; Wageningen Food Safety Research (WFSR), Part of Wageningen University & Research, P.O. Box 230, 6700 AE, Wageningen, The Netherlands.
Jazyk: angličtina
Zdroj: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2022 May; Vol. 414 (11), pp. 3459-3470. Date of Electronic Publication: 2022 Feb 27.
DOI: 10.1007/s00216-022-03967-y
Abstrakt: Due to the absence of chromatographic separation, ambient ionization mass spectrometry had the potential to improve the throughput of control laboratories in the last decades and will soon be an excellent approach for on-site use as well. In this study, an atmospheric solids analysis probe (ASAP) with a single quadrupole mass analyzer has been evaluated to identify anabolic steroid esters rapidly. Sample introduction, applied scan time, and probe temperature were optimized for sensitivity. The in-source fragmentations of seventeen selected steroid esters, commonly found in illicit samples, were determined by applying different cone voltages (12, 20, 30, and 40 V). A spectral library was created for these steroid esters based on the four stages of in-source fragmentation spectra. The applicability of this method was demonstrated for the rapid identification of steroid esters in oily injection solutions, providing test results in less than 2 min.
(© 2022. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje