Multiple early factors anticipate post-acute COVID-19 sequelae.

Autor:	Su Y; Institute for Systems Biology, Seattle, WA 98109, USA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Clinical Research Division, Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Electronic address: suyapeng.tju@gmail.com., Yuan D; Institute for Systems Biology, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA., Chen DG; Institute for Systems Biology, Seattle, WA 98109, USA; Department of Microbiology and Department of Informatics, University of Washington, Seattle, WA 98195, USA., Ng RH; Institute for Systems Biology, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA., Wang K; Institute for Systems Biology, Seattle, WA 98109, USA., Choi J; Institute for Systems Biology, Seattle, WA 98109, USA., Li S; Institute for Systems Biology, Seattle, WA 98109, USA., Hong S; Institute for Systems Biology, Seattle, WA 98109, USA., Zhang R; Institute for Systems Biology, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA., Xie J; Institute for Systems Biology, Seattle, WA 98109, USA; Molecular Engineering & Sciences Institute, University of Washington, Seattle, WA 98105, USA., Kornilov SA; Institute for Systems Biology, Seattle, WA 98109, USA., Scherler K; Institute for Systems Biology, Seattle, WA 98109, USA., Pavlovitch-Bedzyk AJ; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA., Dong S; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA., Lausted C; Institute for Systems Biology, Seattle, WA 98109, USA., Lee I; Institute for Systems Biology, Seattle, WA 98109, USA., Fallen S; Institute for Systems Biology, Seattle, WA 98109, USA., Dai CL; Institute for Systems Biology, Seattle, WA 98109, USA., Baloni P; Institute for Systems Biology, Seattle, WA 98109, USA., Smith B; Institute for Systems Biology, Seattle, WA 98109, USA., Duvvuri VR; Institute for Systems Biology, Seattle, WA 98109, USA., Anderson KG; Clinical Research Division, Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Departments of Immunology and Medicine, University of Washington, Seattle, WA 98109, USA., Li J; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA., Yang F; Department of Pathology, Stanford University, Stanford, CA 94304, USA., Duncombe CJ; Division of Global Health, University of Washington, Seattle, WA 98105, USA., McCulloch DJ; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USA., Rostomily C; Institute for Systems Biology, Seattle, WA 98109, USA., Troisch P; Institute for Systems Biology, Seattle, WA 98109, USA., Zhou J; Isoplexis Corporation, Branford, CT 06405, USA., Mackay S; Isoplexis Corporation, Branford, CT 06405, USA., DeGottardi Q; Adaptive Biotechnologies, Seattle, WA 98109, USA., May DH; Adaptive Biotechnologies, Seattle, WA 98109, USA., Taniguchi R; Adaptive Biotechnologies, Seattle, WA 98109, USA., Gittelman RM; Adaptive Biotechnologies, Seattle, WA 98109, USA., Klinger M; Adaptive Biotechnologies, Seattle, WA 98109, USA., Snyder TM; Adaptive Biotechnologies, Seattle, WA 98109, USA., Roper R; Institute for Systems Biology, Seattle, WA 98109, USA., Wojciechowska G; Institute for Systems Biology, Seattle, WA 98109, USA; Medical University of Białystok, Białystok 15089, Poland., Murray K; Institute for Systems Biology, Seattle, WA 98109, USA., Edmark R; Institute for Systems Biology, Seattle, WA 98109, USA., Evans S; Institute for Systems Biology, Seattle, WA 98109, USA., Jones L; Institute for Systems Biology, Seattle, WA 98109, USA., Zhou Y; Institute for Systems Biology, Seattle, WA 98109, USA., Rowen L; Institute for Systems Biology, Seattle, WA 98109, USA., Liu R; Institute for Systems Biology, Seattle, WA 98109, USA., Chour W; Institute for Systems Biology, Seattle, WA 98109, USA., Algren HA; Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA., Berrington WR; Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA., Wallick JA; Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA., Cochran RA; Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA., Micikas ME; Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA., Wrin T; Monogram Biosciences, South San Francisco, CA 94080, USA., Petropoulos CJ; Monogram Biosciences, South San Francisco, CA 94080, USA., Cole HR; St. John's Cancer Institute at Saint John's Health Center, Santa Monica, CA 90404, USA., Fischer TD; St. John's Cancer Institute at Saint John's Health Center, Santa Monica, CA 90404, USA., Wei W; Institute for Systems Biology, Seattle, WA 98109, USA., Hoon DSB; St. John's Cancer Institute at Saint John's Health Center, Santa Monica, CA 90404, USA., Price ND; Institute for Systems Biology, Seattle, WA 98109, USA., Subramanian N; Institute for Systems Biology, Seattle, WA 98109, USA; Department of Global Heath and Department of Immunology, University of Washington, Seattle, WA 98109, USA., Hill JA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USA., Hadlock J; Institute for Systems Biology, Seattle, WA 98109, USA., Magis AT; Institute for Systems Biology, Seattle, WA 98109, USA., Ribas A; Department of Medicine, University of California, Los Angeles, and Parker Institute for Cancer Immunotherapy, Los Angeles, CA 90095, USA., Lanier LL; Department of Microbiology and Immunology, University of California, San Francisco, and Parker Institute for Cancer Immunotherapy, San Francisco, CA 94143, USA., Boyd SD; Department of Pathology, Stanford University, Stanford, CA 94304, USA., Bluestone JA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA., Chu H; Division of Global Health, University of Washington, Seattle, WA 98105, USA; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USA., Hood L; Institute for Systems Biology, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA., Gottardo R; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Statistics, University of Washington, Seattle, WA 98195, USA; Biomedical Data Sciences, Lausanne University Hospital, University of Lausanne, Lausanne, 1011, Switzerland., Greenberg PD; Clinical Research Division, Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Departments of Immunology and Medicine, University of Washington, Seattle, WA 98109, USA., Davis MM; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; The Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA., Goldman JD; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98109, USA; Swedish Center for Research and Innovation, Swedish Medical Center, Seattle, WA 98109, USA; Providence St. Joseph Health, Renton, WA 98057, USA. Electronic address: jason.goldman@swedish.org., Heath JR; Institute for Systems Biology, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA. Electronic address: jim.heath@isbscience.org.
Jazyk:	angličtina
Zdroj:	Cell [Cell] 2022 Mar 03; Vol. 185 (5), pp. 881-895.e20. Date of Electronic Publication: 2022 Jan 25.
DOI:	10.1016/j.cell.2022.01.014
Abstrakt:	Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However, quantifiable risk factors for PASC and their biological associations are poorly resolved. We executed a deep multi-omic, longitudinal investigation of 309 COVID-19 patients from initial diagnosis to convalescence (2-3 months later), integrated with clinical data and patient-reported symptoms. We resolved four PASC-anticipating risk factors at the time of initial COVID-19 diagnosis: type 2 diabetes, SARS-CoV-2 RNAemia, Epstein-Barr virus viremia, and specific auto-antibodies. In patients with gastrointestinal PASC, SARS-CoV-2-specific and CMV-specific CD8 + T cells exhibited unique dynamics during recovery from COVID-19. Analysis of symptom-associated immunological signatures revealed coordinated immunity polarization into four endotypes, exhibiting divergent acute severity and PASC. We find that immunological associations between PASC factors diminish over time, leading to distinct convalescent immune states. Detectability of most PASC factors at COVID-19 diagnosis emphasizes the importance of early disease measurements for understanding emergent chronic conditions and suggests PASC treatment strategies. Competing Interests: Declaration of interests J.R.H. and A.R. are founders and board members of PACT Pharma. J.R.H. is a board member of Isoplexis, and A.R. is the scientific advisor to Isoplexis. M.M.D. is a member of the Scientific Advisory Board of PACT Pharma. J.A.B. is a member of the Scientific Advisory Boards of Arcus, Solid, and VIR. J.A.B. is a member of the Board of Directors of Gilead and Provention. J.A.B. is the CEO of Sonoma Biotherapeutics. L.L.L. is on the scientific advisory boards of Alector, Atreca, Dragonfly, DrenBio, Nkarta, Obsidian Therapeutics, and SBI Biotech. R.G. has received consulting income from Juno Therapeutics, Takeda, Infotech Soft, Celgene, and Merck, has received research support from Janssen Pharmaceuticals and Juno Therapeutics, and declares ownership in CellSpace Biosciences. P.D.G. is on the Scientific Advisory Board of Celsius, Earli, Elpiscience, Immunoscape, Rapt, and Nextech, was a scientific founder of Juno Therapeutics, and receives research support from Lonza. J.D.G. declared contracted research with Gilead, Lilly, and Regeneron. J.A.H. received consulting fees or honoraria from Gilead Sciences, Amplyx, Allovir, Allogene therapeutics, CRISPR therapeutics, CSL Behring, OptumHealth, Octapharma, and Takeda and research funding from Takeda, Allovir, Karius, and Gilead Sciences. Q.D., D.H.M., R.T., R.M.G., M.K., and T.M.S. have employment and equity ownership with Adaptive Biotechnologies. The remaining authors declare no competing interests. (Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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