Functional Microfiber Nonwoven Fabric with Sialic Acid-Immobilized Polymer Brush for Capturing Lectin in Aerosol.

Autor: Kim YY; Graduate School of Environmental Engineering, The University of Kitakyushu, 1-1 Hibikino, Kitakyushu 808-0135, Japan., Sagara K; Graduate School of Environmental Engineering, The University of Kitakyushu, 1-1 Hibikino, Kitakyushu 808-0135, Japan., Uezu K; Faculty of Environmental Engineering, The University of Kitakyushu, 1-1 Hibikino, Kitakyushu 808-0135, Japan.
Jazyk: angličtina
Zdroj: Polymers [Polymers (Basel)] 2022 Feb 09; Vol. 14 (4). Date of Electronic Publication: 2022 Feb 09.
DOI: 10.3390/polym14040663
Abstrakt: The influenza virus has been known as a representative infectious virus that harms human health from the past to the present day. We have promoted the development of a novel adsorbent capable of adsorbing influenza viruses in the form of aerosols in the air. In this study, to develop a material to adsorb the influenza virus, a functional group was introduced into a microfiber nonwoven fabric (MNWF) manufactured through radiation-induced graft polymerization (RIGP), and sialic acid was immobilized to mimic the sugar chain cluster effect. The functional group was used by coupling disodium iminodiacetate monohydrate (IDA) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), and N -acetylneuraminic acid (NANA) was selected for sialic acid. IDA-EDC was introduced into GMA MNWF with an average molar conversion of 47%. For NANA MNWF with a degree of grafting ( dg ) of 87% introduced with sialic acid, 118.2 of 200 µg of aerosolized lectin was adsorbed, confirming that the maximum adsorption amount was 59.1%. In NANA MNWF of 100% or more dg , a tendency to decrease the amount of lectin adsorption was observed compared to NANA MNWF of 80-100% dg .
Databáze: MEDLINE
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