Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the "Perfect Storm" Theory.

Autor: Tissot S; CREEC/MIVEGEC, Université de Montpellier, CNRS, IRD, 34394 Montpellier, France., Gérard AL; CREEC/MIVEGEC, Université de Montpellier, CNRS, IRD, 34394 Montpellier, France.; Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC 32020, Australia., Boutry J; CREEC/MIVEGEC, Université de Montpellier, CNRS, IRD, 34394 Montpellier, France., Dujon AM; Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC 32020, Australia., Russel T; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia., Siddle H; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK.; Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK., Tasiemski A; Université de Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL-Centre d'Infection et d'Immunité de Lille, 59000 Lille, France., Meliani J; CREEC/MIVEGEC, Université de Montpellier, CNRS, IRD, 34394 Montpellier, France., Hamede R; School of Natural Sciences, University of Tasmania, Hobart, TAS 7001, Australia., Roche B; CREEC/MIVEGEC, Université de Montpellier, CNRS, IRD, 34394 Montpellier, France.; Departamento de Etología, Fauna Silvestre y Animales de Laboratorio, Facultad de Medicina Veterinariay Zootecnia, Universidad Nacional Autónoma de México (UNAM), Ciudad de México 01030, Mexico., Ujvari B; Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC 32020, Australia., Thomas F; CREEC/MIVEGEC, Université de Montpellier, CNRS, IRD, 34394 Montpellier, France.
Jazyk: angličtina
Zdroj: Pathogens (Basel, Switzerland) [Pathogens] 2022 Feb 12; Vol. 11 (2). Date of Electronic Publication: 2022 Feb 12.
DOI: 10.3390/pathogens11020241
Abstrakt: Although the true prevalence of transmissible cancers is not known, these atypical malignancies are likely rare in the wild. The reasons behind this rarity are only partially understood, but the "Perfect Storm hypothesis" suggests that transmissible cancers are infrequent because a precise confluence of tumor and host traits is required for their emergence. This explanation is plausible as transmissible cancers, like all emerging pathogens, will need specific biotic and abiotic conditions to be able to not only emerge, but to spread to detectable levels. Because those conditions would be rarely met, transmissible cancers would rarely spread, and thus most of the time disappear, even though they would regularly appear. Thus, further research is needed to identify the most important factors that can facilitate or block the emergence of transmissible cancers and influence their evolution. Such investigations are particularly relevant given that human activities are increasingly encroaching into wild areas, altering ecosystems and their processes, which can influence the conditions needed for the emergence and spread of transmissible cell lines.
Databáze: MEDLINE
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