| Autor: |
Martín-Contreras M; Department of Applied Physics, University of Granada, Campus Fuentenueva s/n, 18071 Granada, Spain., Navarro-Marchal SA; Department of Applied Physics, University of Granada, Campus Fuentenueva s/n, 18071 Granada, Spain.; Centre for Biomedical Research (CIBM), Biopathology and Regenerative Medicine Institute (IBIMER), University of Granada, 18100 Granada, Spain.; Instituto de Investigación Biosanitaria (ibs.GRANADA), University Hospitals of Granada, University of Granada, 18100 Granada, Spain.; Department of Chemistry in Pharmaceutical Sciences, Faculty of Pharmacy, Complutense University of Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain.; Excellence Research Unit Modeling Nature (MNat), University of Granada, 18071 Granada, Spain., Peula-García JM; Department of Applied Physics II, University of Málaga, 29016 Malaga, Spain.; Biocolloid and Fluid Physics Group, University of Granada, 18071 Granada, Spain., Jódar-Reyes AB; Department of Applied Physics, University of Granada, Campus Fuentenueva s/n, 18071 Granada, Spain.; Excellence Research Unit Modeling Nature (MNat), University of Granada, 18071 Granada, Spain.; Biocolloid and Fluid Physics Group, University of Granada, 18071 Granada, Spain. |
| Abstrakt: |
Nanomedicine against cancer, including diagnosis, prevention and treatment, has increased expectations for the solution of many biomedical challenges in the fight against this disease. In recent decades, an exhaustive design of nanosystems with high specificity, sensitivity and selectivity has been achieved due to a rigorous control over their physicochemical properties and an understanding of the nano-bio interface. However, despite the considerable progress that has been reached in this field, there are still different hurdles that limit the clinical application of these nanosystems, which, along with their possible solutions, have been reviewed in this work. Specifically, physiological processes as biological barriers and protein corona formation related to the administration routes, designing strategies to overcome these obstacles, promising new multifunctional nanotherapeutics, and recent clinical trials are presented in this review. |
