The complex relationship between depression and progression to incident cognitive impairment across race and ethnicity.

Autor:	Babulal GM; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.; Department of Psychology, Faculty of Humanities, University of Johannesburg, Johannesburg, South Africa.; Department of Clinical Research and Leadership, The George Washington University School of Medicine and Health Sciences, Washington, Missouri, USA.; Institute of Public Health, Washington University in St. Louis, St. Louis, Missouri, USA., Zhu Y; School of Social Work, Adelphi University, New York, USA.; Brown School, Washington University in St. Louis, St. Louis, Missouri, USA., Roe CM; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA., Hudson DL; Brown School, Washington University in St. Louis, St. Louis, Missouri, USA.; Institute of Public Health, Washington University in St. Louis, St. Louis, Missouri, USA., Williams MM; New Horizons Living, St. Louis, Missouri, USA., Murphy SA; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA., Doherty J; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA., Johnson AM; Center for Clinical Studies, Washington University in St. Louis, Saint Louis, Missouri, USA., Trani JF; Brown School, Washington University in St. Louis, St. Louis, Missouri, USA.; Institute of Public Health, Washington University in St. Louis, St. Louis, Missouri, USA.; Centre for Social Development in Africa, University of Johannesburg, Johannesburg, South Africa.
Jazyk:	angličtina
Zdroj:	Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2022 Dec; Vol. 18 (12), pp. 2593-2602. Date of Electronic Publication: 2022 Feb 25.
DOI:	10.1002/alz.12631
Abstrakt:	Introduction: We examined baseline differences in depression and antidepressant use among cognitively normal older adults in five ethnoracial groups and assessed whether depression predicted a faster progression to incident cognitive impairment across groups. Methods: Data from the National Alzheimer's Coordinating Center (n = 8168) were used to examine differences between non-Hispanic Whites (nHW), African Americans (AA), Hispanics, Asians, and American Indian and Alaskan Natives in cross-sectional and longitudinal models. Results: AA had a lower risk of depression compared to nHW at baseline. No statistical interactions were noted between ethnoracial groups and depression. However, depression independently predicted a faster progression to incident cognitive impairment. Hispanics and Asian participants had a higher hazard for progression compared to nHW. Discussion: Previously established risk factors between depression and dementia were not found among AA and nHW participants. The relationship between depression and ethnoracial groups is complex and suggests differential effects on progression from cognitive normality to impairment. (© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze:	MEDLINE
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