Could Perimenopausal Estrogen Prevent Breast Cancer? Exploring the Differential Effects of Estrogen-Only Versus Combined Hormone Replacement Therapy.
Autor: | Manyonda I; Department of Obstetrics and Gynaecology, St George's University Hospitals NHS Foundation Trust/St George's, University of London, London, UK., Sinai Talaulikar V; Reproductive Medicine Unit, EGA Wing, University College London Hospital, London NW1 2BU, UK., Pirhadi R; Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University, Chelmsford CM1 1SQ, UK., Ward J; St George's, University of London, London, UK., Banerjee D; Department of Surgery, St George's University Hospitals NHS Foundation Trust, London, UK., Onwude J; The Chelmsford Private Day Surgery Hospital, Fenton House, Chelmsford CM2 0PP, UK. |
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Jazyk: | angličtina |
Zdroj: | Journal of clinical medicine research [J Clin Med Res] 2022 Jan; Vol. 14 (1), pp. 1-7. Date of Electronic Publication: 2022 Jan 29. |
DOI: | 10.14740/jocmr4646 |
Abstrakt: | Breast cancer is the commonest cancer among women in the western world, accounting for up to 30% of all cancers in women. There is a long-standing controversy about the potential link to hormone replacement therapy (HRT), with large observational studies suggesting that HRT increases the risk, while the Women's Health Initiative (WHI), a prospective, randomized placebo-controlled trial, has reported several times over a period of 20 years that combined (estrogen and progestogen) HRT increases the risk, while estrogen-only HRT given to women who have had a prior hysterectomy, is associated with a significantly reduced risk of developing breast cancer. Evidence from the randomized trial shows a significant reduction in both incidence of and mortality from breast cancer in women who took estrogen replacement therapy; this message needs to be presented clearly and robustly so that it can help women with decision making when considering HRT for menopause. Competing Interests: All authors (IM, VST, RP, JW, DB, JO) report no conflict of interest. (Copyright 2022, Manyonda et al.) |
Databáze: | MEDLINE |
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