Endogenous Carboxyhemoglobin Level Variation in COVID-19 and Bacterial Sepsis: A Novel Approach?

Autor:	Grigorescu BL; Department of Pathophysiology, University of Medicine, Pharmacology, Sciences and Technology, 540142 Targu-Mures, Romania., Săplăcan I; Department of Anesthesiology and Intensive Care, Emergency County Hospital, 540136 Targu-Mures, Romania., Bordea IR; Department of Oral Rehabilitation, University of Medicine and Pharmacy Iuliu Hatieganu, 400012 Cluj-Napoca, Romania., Petrisor M; Department of Simulation Applied in Medicine, University of Medicine, Pharmacology, Sciences and Technology, 540142 Targu-Mures, Romania., Coman O; Department of Anesthesiology and Intensive Care, Emergency County Hospital, 540136 Targu-Mures, Romania., Puiac CI; Department of Intensive Care, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu-Mures, Romania., Toncean A; Department of Anesthesiology and Intensive Care, Emergency County Hospital, 540136 Targu-Mures, Romania., Fodor RS; Department of Intensive Care, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu-Mures, Romania.
Jazyk:	angličtina
Zdroj:	Microorganisms [Microorganisms] 2022 Jan 27; Vol. 10 (2). Date of Electronic Publication: 2022 Jan 27.
DOI:	10.3390/microorganisms10020305
Abstrakt:	Background: The increased production of carbon monoxide (CO) in sepsis has been proven, but the blood level variations of carboxyhemoglobin (COHb) as a potential evolutionary parameter of COVID-19 and sepsis/septic shock have yet to be determined. This study aims to evaluate the serum level variation of COHb as a potential evolutionary parameter in COVID-19 critically ill patients and in bacterial sepsis. Materials and Method: A prospective and observational study was conducted on two groups of patients: the bacterial sepsis group ( n = 52) and the COVID-19 group ( n = 52). We followed paraclinical parameters on Day 1 (D1) and Day 5 (D5) of sepsis/ICU admission for COVID-19 patients. Results: D1 of sepsis: statistically significant positive correlations between: COHb values and serum lactate ( p = 0.024, r = 0.316), and total bilirubin ( p = 0.01, r = 0.359). In D5 of sepsis: a statistically significant positive correlations between: COHb values and procalcitonin (PCT) ( p = 0.038, r = 0.402), and total bilirubin ( p = 0.023, r = 0.319). D1 of COVID-19 group: COHb levels were statistically significantly positively correlated with C-reactive protein CRP values ( p = 0.003, r = 0.407) and with PCT values ( p = 0.022, r = 0.324) and statistically significantly negatively correlated with serum lactate values ( p = 0.038, r = -0.285). Conclusion: COHb variation could provide rapid information about the outcome of bacterial sepsis/septic shock, having the advantages of a favorable cost-effectiveness ratio, and availability as a point-of-care test.
Databáze:	MEDLINE
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