African Genomic Medicine Portal: A Web Portal for Biomedical Applications.

Autor: Othman H; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, 9 jubilee Road, Parktown, Johannesburg 2193, South Africa., Zass L; Computational Biology Division, Department of Integrative Biomedical Sciences, IDM, CIDRI Africa Wellcome Trust Centre, University of Cape Town, Rondebosch, Cape Town 7701, South Africa., da Rocha JEB; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, 9 jubilee Road, Parktown, Johannesburg 2193, South Africa.; Division of Human Genetics, National Health Laboratory Service, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2001, South Africa., Radouani F; Chlamydiae and Mycoplasma Laboratory, Research Department, Institut Pasteur du Maroc, Casablanca 20360, Morocco., Samtal C; Laboratory of Biotechnology, Environment, Agri-Food and Health, Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, Fez 30000, Morocco., Benamri I; Chlamydiae and Mycoplasma Laboratory, Research Department, Institut Pasteur du Maroc, Casablanca 20360, Morocco.; Systems and Data Engineering Team, National School of Applied Sciences, Abdelmalek Essaâdi University, Tangier 93000, Morocco., Kumuthini J; South African Bioinformatics Institute, University of Western Cape, Cape Town 7535, South Africa., Fakim YJ; Biotechnology Unit, Department of Agricultural and Food Science, Faculty of Agriculture, University of Mauritius, Reduit 80837, Mauritius., Hamdi Y; Laboratory of Biomedical Genomics and Oncogenetics, LR20IPT05, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis 1002, Tunisia.; Laboratory of Human and Experimental Pathology, Institut Pasteur de Tunis, Tunis 1002, Tunisia., Mezzi N; Laboratory of Biomedical Genomics and Oncogenetics, LR20IPT05, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis 1002, Tunisia.; Department of Biology, Faculty of Science of Bizerte, Jarzouna, Bizerte 7021, Tunisia., Boujemaa M; Laboratory of Biomedical Genomics and Oncogenetics, LR20IPT05, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis 1002, Tunisia., Okeke CJ; Research Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Makhanda 6139, South Africa., Tendwa MB; Research Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Makhanda 6139, South Africa., Sanak K; Chlamydiae and Mycoplasma Laboratory, Research Department, Institut Pasteur du Maroc, Casablanca 20360, Morocco., Chaouch M; Laboratory of Bioinformatics, Biomathematics and Biostatistics, Pasteur Institute of Tunisia, University of Tunis El Manar, Tunis 1068, Tunisia., Panji S; Computational Biology Division, Department of Integrative Biomedical Sciences, IDM, CIDRI Africa Wellcome Trust Centre, University of Cape Town, Rondebosch, Cape Town 7701, South Africa., Kefi R; Laboratory of Biomedical Genomics and Oncogenetics, LR20IPT05, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis 1002, Tunisia., Sallam RM; Basic Medical Science Department, Faculty of Medicine, Galala University, Suez 43727, Egypt.; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo 11381, Egypt., Ghoorah AW; Department of Digital Technologies, Faculty of Information, Communication and Digital Technologies, University of Mauritius, Reduit 80837, Mauritius., Romdhane L; Laboratory of Biomedical Genomics and Oncogenetics, LR20IPT05, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis 1002, Tunisia.; Department of Biology, Faculty of Science of Bizerte, Jarzouna, Bizerte 7021, Tunisia., Kiran A; Malawi-Liverpool-Wellcome Trust, Queen Elizabeth Central Hospital, College of Medicine, Blantyre P.O. Box 30096, Malawi.; Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool L69 3BX, UK., Meintjes AP; Computational Biology Division, Department of Integrative Biomedical Sciences, IDM, CIDRI Africa Wellcome Trust Centre, University of Cape Town, Rondebosch, Cape Town 7701, South Africa., Maturure P; Computational Biology Division, Department of Integrative Biomedical Sciences, IDM, CIDRI Africa Wellcome Trust Centre, University of Cape Town, Rondebosch, Cape Town 7701, South Africa., Jmel H; Laboratory of Biomedical Genomics and Oncogenetics, LR20IPT05, Institut Pasteur de Tunis, University of Tunis El Manar, Tunis 1002, Tunisia., Ksouri A; Laboratory of Venoms and Therapeutic Molecules (LR16IPT08), 1' Place Pasteur, BP74, Pasteur Institute of Tunis, University of Tunis El Manar, Tunis 1002, Tunisia., Azzouzi M; Chlamydiae and Mycoplasma Laboratory, Research Department, Institut Pasteur du Maroc, Casablanca 20360, Morocco., Farahat MA; Compute Science Department, The Higher Future Institute for Specialized Technological Studies, Cairo 11381, Egypt., Ahmed S; Centre for Bioinformatics and Systems Biology, Faculty of Science, University of Khartoum, Khartoum 11115, Sudan., Sibira R; Centre for Bioinformatics and Systems Biology, Faculty of Science, University of Khartoum, Khartoum 11115, Sudan., Turkson MEE; National Institute for Mathematical Sciences, PMB Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana., Ssekagiri A; Division of Entomology and Core Molecular Biology, Bioinformatics Facility, Uganda Virus Research Institute, Entebbe P.O. Box 49, Uganda., Parker Z; Computational Biology Division, Department of Integrative Biomedical Sciences, IDM, CIDRI Africa Wellcome Trust Centre, University of Cape Town, Rondebosch, Cape Town 7701, South Africa., Fadlelmola FM; Centre for Bioinformatics and Systems Biology, Faculty of Science, University of Khartoum, Khartoum 11115, Sudan., Ghedira K; Laboratory of Bioinformatics, Biomathematics and Biostatistics, Pasteur Institute of Tunisia, University of Tunis El Manar, Tunis 1068, Tunisia., Mulder N; Computational Biology Division, Department of Integrative Biomedical Sciences, IDM, CIDRI Africa Wellcome Trust Centre, University of Cape Town, Rondebosch, Cape Town 7701, South Africa., Kamal Kassim S; Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Cairo 11381, Egypt.; MASRI Research Institute, Ain Shams University, Cairo 11381, Egypt.
Jazyk: angličtina
Zdroj: Journal of personalized medicine [J Pers Med] 2022 Feb 11; Vol. 12 (2). Date of Electronic Publication: 2022 Feb 11.
DOI: 10.3390/jpm12020265
Abstrakt: Genomics data are currently being produced at unprecedented rates, resulting in increased knowledge discovery and submission to public data repositories. Despite these advances, genomic information on African-ancestry populations remains significantly low compared with European- and Asian-ancestry populations. This information is typically segmented across several different biomedical data repositories, which often lack sufficient fine-grained structure and annotation to account for the diversity of African populations, leading to many challenges related to the retrieval, representation and findability of such information. To overcome these challenges, we developed the African Genomic Medicine Portal (AGMP), a database that contains metadata on genomic medicine studies conducted on African-ancestry populations. The metadata is curated from two public databases related to genomic medicine, PharmGKB and DisGeNET. The metadata retrieved from these source databases were limited to genomic variants that were associated with disease aetiology or treatment in the context of African-ancestry populations. Over 2000 variants relevant to populations of African ancestry were retrieved. Subsequently, domain experts curated and annotated additional information associated with the studies that reported the variants, including geographical origin, ethnolinguistic group, level of association significance and other relevant study information, such as study design and sample size, where available. The AGMP functions as a dedicated resource through which to access African-specific information on genomics as applied to health research, through querying variants, genes, diseases and drugs. The portal and its corresponding technical documentation, implementation code and content are publicly available.
Databáze: MEDLINE